Publication: Integrated extracellular matrix signaling in mammary
gland development and breast cancer progression
Authors
Zhu, Jieqing ; Xiong, Gaofeng ; Trinkle, Christine ; Xu, Ren
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Extracellular matrix (ECM), a major
component of the cellular microenvironment, plays
critical roles in normal tissue morphogenesis and disease
progression. Binding of ECM to membrane receptor
proteins, such as integrin, discoidin domain receptors,
and dystroglycan, elicits biochemical and biomechanical
signals that control cellular architecture and gene
expression. These ECM signals cooperate with growth
factors and hormones to regulate cell migration,
differentiation, and transformation. ECM signaling is
tightly regulated during normal mammary gland
development. Deposition and alignment of fibrillar
collagens direct migration and invasion of mammary
epithelial cells during branching morphogenesis.
Basement membrane proteins are required for polarized
acinar morphogenesis and milk protein expression.
Deregulation of ECM proteins in the long run is
sufficient to promote breast cancer development and
progression. Recent studies demonstrate that the
integrated biophysical and biochemical signals from
ECM and soluble factors are crucial for normal
mammary gland development as well as breast cancer
progression.
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