Publication:
Integrated extracellular matrix signaling in mammary gland development and breast cancer progression

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dc.contributor.authorZhu, Jieqing
dc.contributor.authorXiong, Gaofeng
dc.contributor.authorTrinkle, Christine
dc.contributor.authorXu, Ren
dc.date.accessioned2019-09-25T13:53:36Z
dc.date.available2019-09-25T13:53:36Z
dc.date.issued2014
dc.description.abstractExtracellular matrix (ECM), a major component of the cellular microenvironment, plays critical roles in normal tissue morphogenesis and disease progression. Binding of ECM to membrane receptor proteins, such as integrin, discoidin domain receptors, and dystroglycan, elicits biochemical and biomechanical signals that control cellular architecture and gene expression. These ECM signals cooperate with growth factors and hormones to regulate cell migration, differentiation, and transformation. ECM signaling is tightly regulated during normal mammary gland development. Deposition and alignment of fibrillar collagens direct migration and invasion of mammary epithelial cells during branching morphogenesis. Basement membrane proteins are required for polarized acinar morphogenesis and milk protein expression. Deregulation of ECM proteins in the long run is sufficient to promote breast cancer development and progression. Recent studies demonstrate that the integrated biophysical and biochemical signals from ECM and soluble factors are crucial for normal mammary gland development as well as breast cancer progression.es
dc.formatapplication/pdfes
dc.format.extent10es
dc.identifier.eisbnHistology and Histopathology, vol. 29, nº 9, (2014)es
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/74882
dc.languageenges
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histologíaes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectExtracellular matrixes
dc.subjectMammary gland developmentes
dc.subjectBreast cancer progressiones
dc.subjectMechanotransductiones
dc.subject.otherCDU::5 - Ciencias puras y naturales::57 - Biología::576 - Biología celular y subcelular. Citologíaes
dc.titleIntegrated extracellular matrix signaling in mammary gland development and breast cancer progressiones
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.29, nº 9 (2014)