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An immunocytochemical method for assaying oestrogen receptors in breast cancers. A comparison with the steroid binding assay

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Date
1988
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Authors
Ottestad, Lars ; Tveit, Kjell M. ; Nesland, Jahn M. ; Dybsjordl, Indrejit ; Bormer, Ole ; Hoie, Johan ; Pihl, Alexander
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The presence of oestrogen receptors was studied in 105 human breast carcinomas using monoclonal antibodies (Abbott ER-ICA kit). The oestrogen receptors of neoplastic cells were semiquantitatively measured and correlations were made to receptor values determined by a dextran-coated charcoal (DCC) steroid binding assay and to histological grade. Immunoreactive cells were found in about 213 of the tumours. Usually only a fraction of the cells within each tumour were immunoreactive, and the staining intensity varied among different cells. In general, well differentiated tumours had a greater proportion of immunoreactive cells than poorly differentiated ones. In most cases (651 98) a good agreement was found between the ER-ICA method and the DCC assay. However, in 33 cases discrepancies were demonstrated.
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Breast carcinomas , Immunocytochemistry
Citation
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http://hdl.handle.net/10201/17928
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Histology and histopathology Vol. 3, nº 3 (1988)
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