Publication:
Understanding glaucomatous damage: Anatomical and functional data from ocular hypertensive rodent retinas

Simple item page
dc.contributor.authorMiralles de Imperial, Jaime
dc.contributor.authorVidal Sanz, Manuel
dc.contributor.authorSalinas Navarro, Manuel Ángel
dc.contributor.authorNadal-Nicolás, Francisco Manuel
dc.contributor.authorValiente Soriano, Francisco Javier
dc.contributor.authorAgudo Barriuso, Marta
dc.contributor.authorVillegas Pérez, Maria Paz
dc.contributor.authorAvilés Trigueros, Marcelino
dc.contributor.authorAlarcón Martínez, Luis
dc.contributor.departmentOftalmología, Optometría, Otorrinolaringología y Anatomía Patológica
dc.contributor.otherFacultades de la UMU::Facultad de Medicina
dc.date.accessioned2026-02-03T09:51:52Z
dc.date.available2026-02-03T09:51:52Z
dc.date.copyright© 2011 Elsevier Ltd.
dc.date.issued2012-01-27
dc.description.abstractGlaucoma, the second most common cause of blindness, is characterized by a progressive loss of retinal ganglion cells and their axons, with a concomitant loss of the visual field. Although the exact pathogenesis of glaucoma is not completely understood, a critical risk factor is the elevation, above normal values, of the intraocular pressure. Consequently, deciphering the anatomical and functional changes occurring in the rodent retina as a result of ocular hypertension has potential value, as it may help elucidate the pathology of retinal ganglion cell degeneration induced by glaucoma in humans. This paper predominantly reviews the cumulative information from our laboratory’s previous, recent and ongoing studies, and discusses the deleterious anatomical and functional effects of ocular hypertension on retinal ganglion cells (RGCs) in adult rodents. In adult rats and mice, perilimbar and episcleral vein photocauterization induces ocular hypertension, which in turn results in devastating damage of the RGC population. In wide triangular sectors, preferentially located in the dorsal retina, RGCs lose their retrograde axonal transport, first by a functional impairment and after by mechanical causes. This axonal damageaffects up to 80% of the RGC population, and eventuallycauses their death, with somal and intraretinal axonal degeneration that resembles that observed after optic nerve crush. Importantly, while ocular hypertension affects the RGC population, it spares non-RGC neurons located in the ganglion cell layer of the retina. In addition, functional and morphological studies show permanent alterations of the inner and outer retinal layers, indicating that further to a crush-like injury of axon bundles in the optic nerve head there may by additional insults to the retina, perhaps of ischemic nature.
dc.formatapplication/pdf
dc.format.extent27
dc.identifier.citationProg Retin Eye Res. 2012 Jan;31(1):1-27.
dc.identifier.doihttps://doi.org/10.1016/j.preteyeres.2011.08.001
dc.identifier.urihttp://hdl.handle.net/10201/198649
dc.languageeng
dc.publisherElsevier
dc.relationSupported in part by research grants from Fundación Séneca 04446/GERM/07; Spanish Ministry of Education and Science SAF-2010-10385; Spanish Ministry of Science and Innovation and ISCIII-FEDER: PI0/70225; PI10/00187, PI006/0780 and Red Temática de Investigación Cooperativa en Oftalmología RD07/0062/0001.
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S1350946211000619?via%3Dihub
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectIntraocular pressure
dc.subjectOptic nerve damage
dc.subjectGlaucoma
dc.subjectRetinal ganglion cells
dc.subjectOcular hypertension
dc.subjectRetinal degeneration
dc.subjectGlaucomatous optic neuropathy
dc.subject.odsObjetivo 3: Salud
dc.titleUnderstanding glaucomatous damage: Anatomical and functional data from ocular hypertensive rodent retinas
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublicationes
relation.isAuthorOfPublication8cc42adf-31e9-49c4-a5e2-476346abe217
relation.isAuthorOfPublication81da925b-fa46-4a1a-96fd-ce35568fa423
relation.isAuthorOfPublicationba9bf053-48ec-4e39-93ac-ffcbaf10fc0f
relation.isAuthorOfPublicationf8fa8514-1382-401e-9e59-8f4604951a09
relation.isAuthorOfPublication5bf27bab-9d43-4b02-a752-5513261676f6
relation.isAuthorOfPublication67ee4a40-a760-4932-9422-ddefd0368452
relation.isAuthorOfPublication03e0f62a-075d-49de-ac29-6b4c980af0b1
relation.isAuthorOfPublicatione3f02ab4-c9cc-4bdf-8476-6afab22c880c
relation.isAuthorOfPublication.latestForDiscovery8cc42adf-31e9-49c4-a5e2-476346abe217
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Vidal-Sanz (ProgRetEyeRes 2012) Understanding Glaucoma.pdf
Size:
6.31 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.37 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Artículos