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Prognostic significance of E-cadherin, β-catenin and cyclin D1 in oral squamous cell carcinoma: a tissue microarray study

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dc.contributor.authorAl-Rawi, Natheer
dc.contributor.authorAl Ani, Muwaffaq
dc.contributor.authorQuadri, Asif
dc.contributor.authorHamdoon, Zaid
dc.contributor.authorAwwad, Aktham
dc.contributor.authorAl Kawas, Sausan
dc.contributor.authorAl Nuaim, Ahmed
dc.date.accessioned2023-01-26T12:06:25Z
dc.date.available2023-01-26T12:06:25Z
dc.date.issued2021
dc.description.abstractObjective. To study the prognostic significance of E-cadherin, β-catenin, and cyclin D1 expression in oral squamous cell carcinoma. Subjects and Methods. The study included 65 subjects with histologically confirmed squamous cell carcinoma. TMA blocks were prepared for immunohistochemical quantification of the expression of the three markers using IHC profiler and Immune ratio plugin of Image J. Results. E-cadherin expression was significantly correlated with histological grades and the metastasis status (p<0.05), whereas β-catenin expression was significantly correlated with smoking and tumor recurrence (P<0.05). Cyclin D1 expression was significantly correlated with depth of invasion and tumor recurrence. (p<0.05). Advanced tumor stage and depth of tumor invasion increases the risk of recurrence or death by 2.5 times (OR=2.53 and 0.84 respectively). Conclusion. High expression of β-catenin and cyclin D1 are significantly correlated with tumor recurrence and old age. Depth of invasion, low histological grade and old age were a significant predictor for the risk of having tumor recurrence and cancer related death.es
dc.formatapplication/pdfes
dc.format.extent11es
dc.identifier.doihttps://doi.org/10.14670/HH-18-363
dc.identifier.eisbnHistology and Histopathology Vol. 36, nº10 (2021)es
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/127900
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectE-cadherines
dc.subjectβ-catenines
dc.subjectCyclin Des
dc.subjectOSCCes
dc.subjectCell adhesiones
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titlePrognostic significance of E-cadherin, β-catenin and cyclin D1 in oral squamous cell carcinoma: a tissue microarray studyes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.36,nº10 (2021)