Publication: Prognostic significance of E-cadherin, β-catenin and cyclin D1 in oral squamous cell carcinoma: a tissue microarray study
Authors
Al-Rawi, Natheer ; Al Ani, Muwaffaq ; Quadri, Asif ; Hamdoon, Zaid ; Awwad, Aktham ; Al Kawas, Sausan ; Al Nuaim, Ahmed
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Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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DOI
https://doi.org/10.14670/HH-18-363
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info:eu-repo/semantics/article
Description
Abstract
Objective. To study the prognostic
significance of E-cadherin, β-catenin, and cyclin D1
expression in oral squamous cell carcinoma.
Subjects and Methods. The study included 65
subjects with histologically confirmed squamous cell
carcinoma. TMA blocks were prepared for
immunohistochemical quantification of the expression of
the three markers using IHC profiler and Immune ratio
plugin of Image J.
Results. E-cadherin expression was significantly
correlated with histological grades and the metastasis
status (p<0.05), whereas β-catenin expression was
significantly correlated with smoking and tumor
recurrence (P<0.05). Cyclin D1 expression was
significantly correlated with depth of invasion and tumor
recurrence. (p<0.05). Advanced tumor stage and depth
of tumor invasion increases the risk of recurrence or
death by 2.5 times (OR=2.53 and 0.84 respectively).
Conclusion. High expression of β-catenin and cyclin
D1 are significantly correlated with tumor recurrence
and old age. Depth of invasion, low histological grade
and old age were a significant predictor for the risk of
having tumor recurrence and cancer related death.
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