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Early endosome autoantigen 1 regulates IL-1β release upon caspase-1 activation independently of gasdermin D membrane permeabilization

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dc.contributor.authorMartín Sánchez, María Rosario Fátima
dc.contributor.authorBaroja Mazo, Alberto
dc.contributor.authorCompan, Vince
dc.contributor.authorTapia Abellán, Ana
dc.contributor.authorCoullin, Isabelle
dc.contributor.authorPelegrín Vivancos, Pablo
dc.contributor.departmentFarmacología
dc.date.accessioned2026-02-25T13:00:35Z
dc.date.available2026-02-25T13:00:35Z
dc.date.copyright© The Author(s) 2019
dc.date.issued2019-04-08
dc.description.abstractUnconventional protein secretion represents an important process of the inflammatory response.The release of the pro-inflammatory cytokine interleukin (IL)-1β which burst during pyroptosis asa consequence of gasdermin D plasma membrane pore formation, can also occur through otherunconventional secretion pathways dependent on caspase-1 activation. However, how caspase-1mediates cytokine release independently of gasdermin D remains poorly understood. Here weshow that following caspase-1 activation by different inflammasomes, caspase-1 cleaves earlyendosome autoantigen 1 (EEA1) protein at Asp127/132 . Caspase-1 activation also results in the releaseof the endosomal EEA1 protein in a gasdermin D-independent manner. EEA1 knock-down resultsin adecreased release of caspase-1 and IL-1β, but the pyroptotic release of other inflammasomecomponents and lactate dehydrogenase was not affected. This study shows how caspase-1 control therelease of EEA1 and IL-1β in a pyroptotic-independent manner
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dc.identifier.citationSci Rep 9, 5788 (2019)
dc.identifier.doihttps://doi.org/10.1038/s41598-019-42298-4
dc.identifier.eissn2045-2322
dc.identifier.urihttp://hdl.handle.net/10201/213362
dc.languageeng
dc.publisherNature Research
dc.relationEste trabajo ha sido financiado por: - European Research Council (ERC-2013-CoG 614578) - Agencia Nacional de Investigación (ANR – Francia)
dc.relation.publisherversionhttps://www.nature.com/articles/s41598-019-42298-4
dc.rightsAttribution 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.odsObjetivo 3: Salud
dc.titleEarly endosome autoantigen 1 regulates IL-1β release upon caspase-1 activation independently of gasdermin D membrane permeabilization
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublicationes
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relation.isAuthorOfPublication547c4c2c-d906-4e1d-ae9a-0cdb40eef6d1
relation.isAuthorOfPublication.latestForDiscoveryeefc2e40-b110-47b5-a081-bcf37256af4c
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