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Melatonin, experimental basis for a possible application in breast cancer prevention and treatment

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dc.contributor.authorCos, S.es
dc.contributor.authorSánchez Barceló, E. J.es
dc.date.accessioned2011-02-22T11:21:26Z
dc.date.available2011-02-22T11:21:26Z
dc.date.issued2000
dc.description.abstractThe role of the pineal as an oncostatic gland has been studied in animal models of tumorigenesis, especially on those concerning the mammary gland. The general conclusion is that experimental manipulations activating pineal gland, or the administration of melatonin, reduce the incidence and growth rate of chemically-induced murine mammary tumors, while pinealectomy or situations which implicate a reduction of melatonin production usually stimulate mammary carcinogenesis. The direct actions of melatonin on mammary tumors have been suggested because of its ability to inhibit, at physiological doses (InM), the in vitro proliferation of MCF-7 human breast cancer cells. In this article we review the outstanding findings related to melatonin actions on mammary which, taken together, support a possible usefulnes of this indoleamine in the prevention and treatment of mammary gland malignancy.es
dc.formatapplication/pdfes
dc.format.extent11es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/19315
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectMelatonines
dc.subjectPineal glandes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleMelatonin, experimental basis for a possible application in breast cancer prevention and treatmentes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.15, nº 2 (2000)