Publication: Melatonin, experimental basis for a possible application in breast cancer prevention and treatment
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Date
2000
Authors
Cos, S. ; Sánchez Barceló, E. J.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The role of the pineal as an oncostatic gland
has been studied in animal models of tumorigenesis,
especially on those concerning the mammary gland. The
general conclusion is that experimental manipulations
activating pineal gland, or the administration of
melatonin, reduce the incidence and growth rate of
chemically-induced murine mammary tumors, while
pinealectomy or situations which implicate a reduction
of melatonin production usually stimulate mammary
carcinogenesis. The direct actions of melatonin on
mammary tumors have been suggested because of its
ability to inhibit, at physiological doses (InM), the in
vitro proliferation of MCF-7 human breast cancer cells.
In this article we review the outstanding findings related
to melatonin actions on mammary which, taken together,
support a possible usefulnes of this indoleamine in the
prevention and treatment of mammary gland
malignancy.
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Citation
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