Publication: Abnormal development of the notochord and perinotochordal sheath in duplicitas posterior, patch and tail-short mice
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Date
1988
Authors
Center, Elizabeth M. ; Marcus, Normala M. ; Wilson, D.B.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Interest in developmental interactions
involving the notochord and perinotochordal sheath led
to a comparative investigation of these structures in three
mouse mutants. Alcian blue or periodic acid-Schiff
staining of 9 1/2-13 days' gestational age embryos
revealed a supernumerary notochordal-like mass of cells
or a deflected notochord in association with duplication
of the neural tube in mice of the duplicitas posterior
stock. The perinotochordal sheath and basement
membrane of the accessory notochordal masses were
frequently defective. Patch and Tail-short embryos were
also utilized for study by means of light rnicroscopy using
Alcian blue staining. In Patch embryos, although the
notochord was sometimes compressed dorso-ventrally . it
had an intact perinotochordal sheath and a defined,
but undulated, basement membrane. Mesenchymal cells
between the notochord and neural tube were occasionally
replaced by cell-free space. In contrast, in Tail-short
embryos a poorly formed, lightly staining or totally
absent notochordal sheath was revealed. Indeed, it was
sometimes difficult to distinguish the notochord from
surrounding mesenchymal cells. In both the Patch and
Tail-short embryos the notochord was also deflected
from its media1 position. In the three mutants studied,
the director indirect effect of gene action appeared to be
on the notochord and perinotochordal sheath. and the
important role of these structures in abnormal axial
development was established.
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