Disparity between central and peripheral refraction inheritance in twins

Pusti, D.; Benito, A.; Madrid-Valero, J.J.; Ordoñana, J.R.; Artal, P.

Publication:
Disparity between central and peripheral refraction inheritance in twins

dc.contributor.author	Pusti, D.
dc.contributor.author	Benito, A.
dc.contributor.author	Madrid-Valero, J.J.
dc.contributor.author	Ordoñana, J.R.
dc.contributor.author	Artal, P.
dc.contributor.department	Física
dc.date.accessioned	2025-01-15T09:27:00Z
dc.date.available	2025-01-15T09:27:00Z
dc.date.issued	2021-06-09
dc.description	© 2021 The authors This document is the published version of a published work that appeared in final form in Scientific Reports This document is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0 To access the final edited and published work see: https://doi.org/10.1038/s41598-021-90838-8
dc.description.abstract	The last decades have witnessed a sudden increase in myopia incidence among youngsters that have been related to modern lifestyle along with the use of emerging technologies affecting visual exposure. Increasing exposures to known risk factors for myopia, such as time spent indoors, close-distance work, or low-light conditions are thought to be responsible for this public health issue. In most cases, development of myopia is secondary to a vitreous chamber enlargement, although the related mechanisms and the potential interaction between central and peripheral retinal area remain unclear. For a better understanding, we performed a classical twin study where objective refractive error along 70° of horizontal retinal arc was measured in 100 twin pairs of university students, 78% of which showed manifest myopia. We found the variance of shared environmental origin (range 0.34 to 0.67) explained most of the objective refractive error variance within central 42° of the retina (22° temporal to 19° nasal), whereas additive genetic variance (range 0.34 to 0.76) was predominant in the peripheral retinal areas measured. In this sample of millennial university students, with a large prevalence of myopia, environmental exposures were mostly responsible for inter-individual variation in the retinal horizontal area surrounding the macula, while their relative weight on phenotypic variance was gradually descending, and replaced by the variance of genetic origin, towards the retinal periphery.	es
dc.format	application/pdf	es
dc.format.extent	7	es
dc.identifier.doi	https://doi.org/10.1038/s41598-021-90838-8
dc.identifier.eisbn	Scientific Reports, volumen 11, número 1 (2021)	es
dc.identifier.issn	2045-2322
dc.identifier.uri	http://hdl.handle.net/10201/148464
dc.language	eng	es
dc.publisher	Nature Research	es
dc.relation	This study was supported by MyFUN (Myopia Fundamental Understanding Needed): European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 675137.	es
dc.rights	info:eu-repo/semantics/openAccess	es
dc.rights	Attribution-NonCommercial-NoDerivatives 4.0 Internacional	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/	*
dc.subject	Peripheral	es
dc.subject	Foveal
dc.subject	Refraction
dc.subject	Twins
dc.subject	Inheritance
dc.title	Disparity between central and peripheral refraction inheritance in twins	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es