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Tissue and molecular events in human conjunctival scarring in ocular cicatricial pemphigoid

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dc.contributor.authorRazzaque, M. S.
dc.contributor.authorFoster, C. S.
dc.contributor.authorAhmed, A. R.
dc.date.accessioned2020-09-18T16:28:12Z
dc.date.available2020-09-18T16:28:12Z
dc.date.issued2001
dc.description.abstractDetail ed histomo rph ometric analysis of human conjunctiva l biopsy specimens has convincingly demonstrated that tissue remodeling of the extracellular matri x (EC M) is an esse nti al and dy nami c process associated with conjuncti val sca rring in ocul ar cicatricial pemphi go id (OCP). The co njun cti va l sca rring ofte n eventuall y results in impaired vision and/or blindness. The molecul ar mechanisms of conjunctival scarring are not compl etely und erstood. Acc umulating evidence indicates that the earl y phase of conjunctival fibrosis is linked with an immuno-inflammatory process medi ated by cy tokines released by ac tiva ted conjunctiv al cells and/or by infiltrating cells. Fibrogenic cytokines secreted by infl ammatory cells and fibroblasts might acti vely be in vo lve d in remode lin g o f th e matri x within th e conjunctival stroma, possibly by regul ating the altered metabolism of matrix proteins.es
dc.formatapplication/pdfes
dc.format.extent10es
dc.identifier.eisbnHistology and histopathology, Vol.16, nº 4 (2001)es
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/96152
dc.languageenges
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histologíaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectOcular cicatricial pemphigoides
dc.subjectConjunctivaes
dc.subjectFibrosises
dc.subjectCollagenes
dc.subjectTransforming growth factor-ß1es
dc.subjectHeat shock protein 47es
dc.subject.otherCDU::5 - Ciencias puras y naturales::57 - Biología::576 - Biología celular y subcelular. Citologíaes
dc.titleTissue and molecular events in human conjunctival scarring in ocular cicatricial pemphigoides
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.16, nº 4 (2001)