Publication: Tissue and molecular events in human
conjunctival scarring in ocular cicatricial pemphigoid
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Date
2001
Authors
Razzaque, M. S. ; Foster, C. S. ; Ahmed, A. R.
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Detail ed histomo rph ometric analysis of
human conjunctiva l biopsy specimens has convincingly
demonstrated that tissue remodeling of the extracellular
matri x (EC M) is an esse nti al and dy nami c process
associated with conjuncti val sca rring in ocul ar cicatricial
pemphi go id (OCP). The co njun cti va l sca rring ofte n
eventuall y results in impaired vision and/or blindness.
The molecul ar mechanisms of conjunctival scarring are
not compl etely und erstood. Acc umulating evidence
indicates that the earl y phase of conjunctival fibrosis is
linked with an immuno-inflammatory process medi ated
by cy tokines released by ac tiva ted conjunctiv al cells
and/or by infiltrating cells. Fibrogenic cytokines secreted
by infl ammatory cells and fibroblasts might acti vely be
in vo lve d in remode lin g o f th e matri x within th e
conjunctival stroma, possibly by regul ating the altered
metabolism of matrix proteins.
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Citation
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