Víllora Cano, Gloria

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Víllora Cano, Gloria

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Víllora Cano, Gloria

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Universidad de Murcia. Departamento de Ingeniería Química

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Open Access
Liquid-liquid equilibra for ternary mixtures of 1-alkyl-3-methyl imidazolium bis{(trifluoromethyl)sulfonyl}imides, n-hexane and organic compounds at 303.15 K and 0.1 MPa
( Elsevier , 2016-08-30) García Montalbán, Mercedes; Trigo, Rocío; Collado-González, Mar; Díaz Baños, F. Guillermo; Víllora Cano, Gloria; Ingeniería Química
Ternary liquid–liquid equilibria were experimentally determined for eight systems composed of an ionic liquid + n-hexane + an organic compound implicated in the racemic resolution of rac-2-pentanol (rac-2-pentanol, vinyl butyrate, rac-2-pentyl butyrate or butyric acid) at a temperature of 303.15 K and pressure of 0.1MPa. The following ionic liquids were used: 1-ethyl-3-methylimidazolium bis{(trifluoromethyl)sulfonyl}imide, [emim+][NTf2-], and 1-hexyl-3-methylimidazolium bis{(trifluoromethyl)sulfonyl}imide, [hmim+][NTf2-]. The binodal curves and the tie line of the conjugate phases compositions were determined through measurement of the refractive index for the ionic liquid-rich phase and by using gas chromatography for the hexane-rich phase, enabling their potential to be assessed for selective extraction of organic compounds from a mixture of ionic liquid reaction media for the resolution of rac-2-pentanol. Liquid phase activity coefficients were calculated using the Non-Random Two-Liquid equation and the tie line theoretical data calculated from the model are in good agreement with the experimental data. As yet, the literature contains no data for the systems studied in this paper.
Open Access
Aggregation behaviour of gold nanoparticles in presence of chitosan
(Springer, 2015-06-13) Fernández Espín, Vanesa ; Pamies, Ramón ; García de la Torre, José; García Montalbán, Mercedes; collado; Collado-González, Mar; Hernández Cifre, José Ginés; Díaz Baños, F. Guillermo; Víllora Cano, Gloria; Ingeniería Química
Chitosan (CS) is a biocompatible polysaccharide with positive charge that is widely used as a coating agent for negatively charged nanoparticles. However, the types of structures that emerge by combining CS and anoparticles as well as their behaviour are still poorly understood. In this work, we characterize the nanocomposites formed by gold nanoparticles (AuNPs) and CS and study the influence of CS in the expected aggregation process that should experience those nanoparticles under the favourable conditions of low pH and high ionic strength. Thus, at the working CS concentration, we observe the existence of CS structures that quickly trap the AuNPs and avoid the formation of nanoparticle aggregates in environmental conditions that, otherwise, would lead to such an aggregation.
Open Access
Density and refractive index data of binary and ternary mixtures of imidazolium-based ionic liquids, n-hexane and organic compounds involved in the kinetic resolution of rac-2-pentanol
(Elsevier, 2018-05-05) García Montalbán, Mercedes; Collado-González, Mar; Lozano-Pérez, A. Abel; Díaz Baños, F. Guillermo; Víllora Cano, Gloria; Ingeniería Química
This data article is related to the subject of the research article “Extraction of Organic Compounds Involved in the Kinetic Resolution of rac-2-Pentanol from n-hexane by Imidazolium-based Ionic Liquids:Liquid-LiquidEquilibrium” (Montalbán etal.,2018) [1]. It contains experimental data of density and refractive index of binary and ternary mixtures of imidazolium-based ionic liquids, n-hexane and organic compounds involved in the kinetic resolution of rac-2-pentanol (rac-2-pentanol, vinylbutyrate, rac-2-pentyl butyrate or butyric acid) measured at 303.15 K and 1 atm. These data are presented as calibration curves which help to determine the composition of the ionic liquid-rich phase knowing its density or refractive index.
Open Access
Assessing chemical toxicity of ionic liquids on Vibrio ﬁscheri: Correlation with structure and composition
(Pergamon – Elsevier Science Ltd, 2016-04-11) Hidalgo, Juana M; García Montalbán, Mercedes; Salinas Hidalgo, María Dolores; Collado-González, Mar; Díaz Baños, F. Guillermo; Víllora Cano, Gloria; Biología Celular e Histología
One of the most important properties of the ionic liquids (ILs) is their non-volatility. However, they are wide soluble in water. For this reason, they can be released to aquatic ecosystems and to contribute to water pollution. Nevertheless, toxicological data related to ionic liquids is scarce in literature because of the great number of possible ionic liquids synthesized. The present work reports the toxicity of twenty-nine imidazolium-, pyridinium- and ammonium-based ionic liquids towards the luminescent bacteria Vibrio fischeri. Some of the effects analyzed on the toxicity have been the type of anion, the length of the alkyl chain of the cation, the cation core and the presence of a functionalized side chain in the cation. These results have showed that the main influence on the toxicity of the ILs is the alkyl chain length. A Quantitative Structure-Activity Relationships (QSAR) method has been used to validate our results obtaining a very good agreement.
Open Access
Caracterización de nanoestructuras de quitosano, fibroína de seda y oro como liberadores de fármacos
(Universidad de Murcia, 2018) Collado-González, Mar; Díaz Baños, F. Guillermo; Víllora Cano, Gloria
En las últimas décadas la nanomedicina ha experimentado un avance significativo en la síntesis de sistemas de liberación de fármacos; ya que mejoran la eficacia terapéutica de los tratamientos aplicados 1 . Un aspecto de especial relevancia es la agregación que experimentan algunos nanosistemas al ser expuestos a condiciones fisiológicas, ya que la baja estabilidad coloidal modifica su actividad biológica y, si tienen que viajar a través del torrente sanguíneo hasta llegar a su sitio de acción, los agregados pueden provocar situaciones que desemboquen en la formación de trombos o embolias. En esta Tesis Doctoral se utiliza quitosano como agente estabilizador de diferentes nanosistemas que agregan al ser expuestos a condiciones fisiológicas
Open Access
Chitosan as stabilizing agent for negatively charged nanoparticles
(Elsevier, 2016-12-24) Collado-González, Mar; García Montalbán, Mercedes; Peña-García, Jorge; Pérez-Sánchez, Horacio; Víllora Cano, Gloria; Díaz Baños, F. Guillermo; Biología Celular e Histología
Chitosan is a biocompatible polysaccharide with positive Z potential which can stabilize negative charged nanoparticles. Silk fibroin nanoparticles and citrate gold nanoparticles, both with negative Z potential, but they form aggregates at physiological ionic strength. In this work, we study the behavior of chitosan in solution when the ionic strength of the medium is increased and how the concentration of chitosan and the proportion of the two components (chitosan and AuNP or SFN) significantly affect the stability and size of the nanocomposites formed. In addition to experimental measurements, molecular modeling were used to gain insight into how chitosan interacts with silk fibroin monomers, and to identify the main energetic interactions involved in the process. The optimum values for obtaining the smallest and most homogeneous stable nanocomposites were obtained and two different ways of organization through which chitosan may exert its stabilizing effect were suggested.
Open Access
Extraction of Organic Compounds Involved in the Kinetic Resolution of rac-2-Pentanol from n-Hexane by Imidazolium-based Ionic Liquids: Liquid-Liquid Equilibrium
(Elsevier B.V., 2018) García Montalbán, Mercedes; Collado-González, Mar; Lozano-Pérez, A. Abel; Díaz Baños, F. Guillermo; Víllora Cano, Gloria; Química Física
This paper focuses on the use of ionic liquids (1-butyl-3-methylimidazolium methylsulphate, [bmim+][MeSO4-], and 1-ethyl-3-methylimidazolium acetate, [emim+][Ac-]) to extract organic compounds involved in the racemic resolution of rac-2-pentanol (rac-2-pentanol, vinyl butyrate, rac-2-pentyl butyrate or butyric acid) from a mixture of one of these organic compounds with n-hexane. Liquid–liquid equilibrium data were experimentally obtained for seven ternary systems comprising an ionic liquid + rac-2-pentanol, vinyl butyrate, rac-2-pentyl butyrate or butyric acid + n-hexane at T=303.15 K and atmospheric pressure. Binodal curves were measured applying the well-known procedure based on the observance of the cloud point while the compositions of the tie lines were calculated from refractive index and density measurements (the phase rich in the ionic liquid) and by gas cromatography (the phase rich in n-hexane). Selectivity values and the solute distribution ratio were utilized to test the possibility of the use of these ionic liquids as extractive solvents of the organic compounds implicated in the kinetic separation of the R- and S-enantiomers of rac-2-pentanol. The liquid-liquid equilibrium data of the ternary systems examined here have not previously been described in the literature.