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Pérez Fernández, Virginia

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Pérez Fernández, Virginia
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Universidad de Murcia. Departamento de Ciencias Sociosanitarias
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    Breastmilk polyamines modify gut gene expression in children at three months of age
    (Elsevier, 2025-01-22) Sánchez-Campillo, María; Gázquez García, Antonio; Pastor-Fajardo, María T.; López-Andreo, María J.; Pérez-Andrés, Adrián; Martínez Gracia, Carmen; Vioque, Jesús; Pérez Fernández, Virginia; García-Marcos Álvarez, Luis Vicente; Larqué Daza, Elvira; Nela Study Group; Tecnología de Alimentos, Nutrición y Bromatología; Facultad de Veterinaria
    Background & aims: Breastmilk is one of the main sources of exogenous polyamines for newborns and contains higher polyamine content than infant formulas. Polyamines are involved in gut maturation and immune system regulation in animals, although the underlying mechanisms are not fully understood. We quantified polyamines in human mature breastmilk and evaluate their effects on intestinal gene expression in babies at three months of age. Methods: Polyamines were quantified in mature milk of 195 women from the prospective Mediterranean NELA birth cohort (Murcia, Spain) at 3 months postpartum. Maternal dietary intake was assessed by food frequency questionnaires. Intestinal gene expression was analysed in babies receiving breastmilk, with high (>p50, n = 25) or low (
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    Serum vitamins A and E at mid-pregnancy and their relationships with both maternal and cord blood antioxidant status and perinatal conditions: The NELA Cohort
    (2023-06-02) Sánchez-Campillo, María; Gázquez García, Antonio; Serrano-Munuera, Ana; Bañón Arnao, Marino; Avilés Plaza, Francisco Valeriano; Garcia-Serna, Azahara M.; Noguera Velasco, José Antonio; Martínez López de Castro, Ana María; Martínez Gracia, Carmen; Suárez Martínez, Clara; Santaella-Pascual, Marina; Vioque, Jesús; Montoya-Hernández, Carmen; Ballesteros Meseguer, Carmen; Sánchez Ferrer, María Luisa; Pérez Fernández, Virginia; Morales Bartolomé, Eva; García-Marcos Álvarez, Luis Vicente; Larqué Daza, Elvira; Nela Study Group; Tecnología de Alimentos, Nutrición y Bromatología; Facultad de Veterinaria
    Introduction: Most of the pregnant women do not achieve the recommended dietary intake of vitamins A and E. These vitamins may counteract oxidative stress involved in some adverse perinatal outcomes. We aimed to assess the associations between maternal vitamin A and E at mid-pregnancy with both maternal and fetal outcomes and to identify possible early biomarkers during pregnancy to predict and prevent oxidative stress in the offspring. Methods: Data on dietary and serum levels of vitamins A and E were collected from 544 pregnant women from the Nutrition in Early Life and Asthma (NELA) study, a prospective mother-child cohort set up in Spain. Results: There were large discrepancies between low dietary vitamin E intake (78% of the mothers) and low serum vitamin E levels (3%) at 24 weeks of gestation. Maternal serum vitamins A and E at mid-pregnancy were associated with higher antioxidant status not only in the mother at this time point (lower hydroperoxides and higher total antioxidant activity [TAA]) but also with the newborn at birth (higher TAA). Gestational diabetes mellitus (GDM) was negatively associated with maternal serum vitamin A (OR: 0.95 CI: 0.91–0.99, p = 0.009) at mid-pregnancy. Nevertheless, we could not detect any association between GDM and oxidative stress parameters. Conclusions: In conclusion, maternal vitamin A and E serum levels may be used as an early potential biomarker of antioxidant status of the neonate at birth. Control of these vitamins during pregnancy could help avoid morbid conditions in the newborn caused by oxidative stress in GDM pregnancies.
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