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10.14670/HH-30.737
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Título: | Beneficial effects of cannabinoid receptor type 2 (CB2R) in injured skeletal muscle post-contusion |
Fecha de publicación: | 2015 |
Editorial: | F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología |
Cita bibliográfica: | Histology and Histopathology, vol.30, nº 6, (2015) |
ISSN: | 1699-5848 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología |
Palabras clave: | Muscle injury Fibrosis Regeneration Cannabinoid receptor type 2 (CB2R) |
Resumen: | The aim of the current study was to investigate the effects of cannabinoid receptor type 2 (CB2R) on the repair process of injured skeletal muscle, which could potentially lay solid foundations as a novel target for curing muscular fibrosis in future. A standardized rat model of skeletal muscle contusion was established, where rats were treated with the CB2R agonist JWH-133 or antagonist AM-630. The in vivo results revealed that CB2R activation with JWH-133 significantly diminished the fibrotic areas, downregulated the mRNA levels of collagen type I/ІІІ and augmented the number of multinucleated regenerating myofibers in the injured zones. The reasons leading to the aforementioned results were directly attributable to decreased mRNA levels of TGF-β1, FN-EIIIA and αSMA, reduced accumulation of myofibroblasts, and concomitantly increased mRNA levels of matrix metalloproteinase-1/2. However, we observed contrasting changes in rats treated with the CB2R antagonist AM-630. These results revealed multiple effects of CB2R in systematically inhibiting fibrotic formation and improving muscle regeneration, alongside its potential for clinical application in patients with skeletal muscle injuries and diseases. |
Autor/es principal/es: | Yu, Tianshui Wang, Xu Zhao, Rui Zheng, Jilong Li, Liqiang Ma, Wenxiang Zhang, Shutao Zhang Guan, Dawei |
URI: | http://hdl.handle.net/10201/96145 |
DOI: | 10.14670/HH-30.737 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 13 |
Derechos: | info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 International |
Aparece en las colecciones: | Vol.30, nº6 (2015) |
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Fichero | Descripción | Tamaño | Formato | |
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Yu-30-737-749-2015.pdf | 6,25 MB | Adobe PDF | Visualizar/Abrir |
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