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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Yu, Tianshui | - |
dc.contributor.author | Wang, Xu | - |
dc.contributor.author | Zhao, Rui | - |
dc.contributor.author | Zheng, Jilong | - |
dc.contributor.author | Li, Liqiang | - |
dc.contributor.author | Ma, Wenxiang | - |
dc.contributor.author | Zhang, Shutao Zhang | - |
dc.contributor.author | Guan, Dawei | - |
dc.date.accessioned | 2020-09-18T11:58:05Z | - |
dc.date.available | 2020-09-18T11:58:05Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | Histology and Histopathology, vol.30, nº 6, (2015) | es |
dc.identifier.issn | 1699-5848 | - |
dc.identifier.uri | http://hdl.handle.net/10201/96145 | - |
dc.description.abstract | The aim of the current study was to investigate the effects of cannabinoid receptor type 2 (CB2R) on the repair process of injured skeletal muscle, which could potentially lay solid foundations as a novel target for curing muscular fibrosis in future. A standardized rat model of skeletal muscle contusion was established, where rats were treated with the CB2R agonist JWH-133 or antagonist AM-630. The in vivo results revealed that CB2R activation with JWH-133 significantly diminished the fibrotic areas, downregulated the mRNA levels of collagen type I/ІІІ and augmented the number of multinucleated regenerating myofibers in the injured zones. The reasons leading to the aforementioned results were directly attributable to decreased mRNA levels of TGF-β1, FN-EIIIA and αSMA, reduced accumulation of myofibroblasts, and concomitantly increased mRNA levels of matrix metalloproteinase-1/2. However, we observed contrasting changes in rats treated with the CB2R antagonist AM-630. These results revealed multiple effects of CB2R in systematically inhibiting fibrotic formation and improving muscle regeneration, alongside its potential for clinical application in patients with skeletal muscle injuries and diseases. | es |
dc.format | application/pdf | es |
dc.format.extent | 13 | es |
dc.language | eng | es |
dc.publisher | F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología | es |
dc.relation | Sin financiación externa a la universidad | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Muscle injury | es |
dc.subject | Fibrosis | es |
dc.subject | Regeneration | es |
dc.subject | Cannabinoid receptor type 2 (CB2R) | es |
dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología | es |
dc.title | Beneficial effects of cannabinoid receptor type 2 (CB2R) in injured skeletal muscle post-contusion | es |
dc.type | info:eu-repo/semantics/article | es |
dc.identifier.doi | 10.14670/HH-30.737 | - |
Aparece en las colecciones: | Vol.30, nº6 (2015) |
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Yu-30-737-749-2015.pdf | 6,25 MB | Adobe PDF | Visualizar/Abrir |
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