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Título: | Myeloid CD11c+ S100+ dendritic cells express indoleamine 2,3-dioxygenase at the inflammatory border to invasive lower lip squamous cell carcinoma |
Fecha de publicación: | 2011 |
Editorial: | Editores F. Hernandez y Juan F. Madrid. Murcia, Universidad de Murcia, Departamento de Biologia Celular e Histologia |
ISSN: | 1699-5848 0213-3911 |
Materias relacionadas: | 61 - Medicina |
Palabras clave: | Indoleamine 2 3-dioxigenase Squamous cell carcinoma |
Resumen: | The prevalence of squamous cell carcinoma of the lower lip (SCC-LL) is increasing worlwide. The expression of the enzyme indoleamine 2,3-dioxygenase (IDO) by antigen-presenting cells and/or tumor cells leads to tumor escape by inhibiting T cell-mediated rejection responses. The aim of this study was to determine the expression of IDO in SCC-LL. IDOexpression was analyzed in 47 SCC-LL, together with the expression of markers of T-cells (CD3), myeloid DCs (S100, CD11c), macrophages (CD68, CD11c), Langerhans cells (CD1a, Langerin (CD207)), plasmacytoid DCs (CD123), and regulatory T cells (Foxp3) by immunohistochemistry and immunofluorescence analysis. Twelve specimens out of 47 LLSCCs contained cells that expressed IDO. IDO-positivity was strongly associated with the intensity of the cancerassociated infiltrate (P=0.0007). IDO-positive cells are located right along the border between the developing tumor and the inflammatory infiltrate. Immunofluorescence stainings showed that CD11c+S100+CD68- dendritic cells (DCs) express IDO in SCC-LL. IDO expression in LL-SCC may aid immune escape and chronic inflammation to promote cancer progression. Inhibition of IDO might be a therapeutic strategy to increase the anti-tumor immune response in SCC-LL. |
Autor/es principal/es: | Kuales, Melanie Alice Wenzel, Jörg Schmid-Wendtner, Monika-Hildegard Bieber, Thomas Bubnoff, Dagmar von |
Forma parte de: | Histology and Histopathology, vol26, nº8, 2011 |
URI: | http://hdl.handle.net/10201/49481 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 10 |
Derechos: | info:eu-repo/semantics/openAccess |
Matería temporal: | 2011 |
Aparece en las colecciones: | Vol.26, nº8 (2011) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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Kuales-26-997-1006-2011.pdf | 2,81 MB | Adobe PDF | Visualizar/Abrir |
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