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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Kuales, Melanie Alice | - |
dc.contributor.author | Wenzel, Jörg | - |
dc.contributor.author | Schmid-Wendtner, Monika-Hildegard | - |
dc.contributor.author | Bieber, Thomas | - |
dc.contributor.author | Bubnoff, Dagmar von | - |
dc.coverage.temporal | 2011 | es |
dc.date.accessioned | 2016-05-02T10:40:59Z | - |
dc.date.available | 2016-05-02T10:40:59Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1699-5848 | - |
dc.identifier.issn | 0213-3911 | - |
dc.identifier.uri | http://hdl.handle.net/10201/49481 | - |
dc.description.abstract | The prevalence of squamous cell carcinoma of the lower lip (SCC-LL) is increasing worlwide. The expression of the enzyme indoleamine 2,3-dioxygenase (IDO) by antigen-presenting cells and/or tumor cells leads to tumor escape by inhibiting T cell-mediated rejection responses. The aim of this study was to determine the expression of IDO in SCC-LL. IDOexpression was analyzed in 47 SCC-LL, together with the expression of markers of T-cells (CD3), myeloid DCs (S100, CD11c), macrophages (CD68, CD11c), Langerhans cells (CD1a, Langerin (CD207)), plasmacytoid DCs (CD123), and regulatory T cells (Foxp3) by immunohistochemistry and immunofluorescence analysis. Twelve specimens out of 47 LLSCCs contained cells that expressed IDO. IDO-positivity was strongly associated with the intensity of the cancerassociated infiltrate (P=0.0007). IDO-positive cells are located right along the border between the developing tumor and the inflammatory infiltrate. Immunofluorescence stainings showed that CD11c+S100+CD68- dendritic cells (DCs) express IDO in SCC-LL. IDO expression in LL-SCC may aid immune escape and chronic inflammation to promote cancer progression. Inhibition of IDO might be a therapeutic strategy to increase the anti-tumor immune response in SCC-LL. | es |
dc.format | application/pdf | es |
dc.format.extent | 10 | es |
dc.language | eng | es |
dc.publisher | Editores F. Hernandez y Juan F. Madrid. Murcia, Universidad de Murcia, Departamento de Biologia Celular e Histologia | es |
dc.relation.ispartof | Histology and Histopathology, vol26, nº8, 2011 | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Indoleamine 2 | es |
dc.subject | 3-dioxigenase | es |
dc.subject | Squamous cell carcinoma | es |
dc.subject.other | 61 - Medicina | es |
dc.title | Myeloid CD11c+ S100+ dendritic cells express indoleamine 2,3-dioxygenase at the inflammatory border to invasive lower lip squamous cell carcinoma | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.26, nº8 (2011) |
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Fichero | Descripción | Tamaño | Formato | |
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Kuales-26-997-1006-2011.pdf | 2,81 MB | Adobe PDF | Visualizar/Abrir |
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