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Título: | Significance of α-SMA in myofibroblasts emerging in renal tubulointerstitial fibrosis |
Fecha de publicación: | 2011 |
Editorial: | F. Hernández y Juan F. Madrid. Murcia: Universidad de Murcia, Departamento de Biología Celular e Histología |
ISSN: | 1699-5848 0213-3911 |
Materias relacionadas: | 611 - Anatomía |
Palabras clave: | Renal fibrosis Myofibroblast |
Resumen: | Myofibroblast transdifferentiation plays a crucial role in the development and progression of renal tubulointerstitial fibrosis. However, the significance of α-smooth muscle actin (α-SMA) expression, which is the major morphological characteristic of myofibroblasts, remains to be determined in detail. The effect of α-SMA expression on fibrosis tissue was examined by using a fibrosis model (collagen gel) in vitro. The transdifferentiation of fibroblasts into myofibroblasts was triggered in the culture medium with 0.5% fetal bovine serum (FBS)+transforming growth factor (TGF)- ß1, but not with 10% FBS+TGF-ß1. The TGF-ß1- induced gel contraction caused by myofibroblasts was greater than that by fibroblasts. Gel contraction by myofibroblasts involved the Ca2+-dependent myosin light chain kinase pathway, as well as the activation of Rho kinase and p38 mitogen-activated protein kinase (MAPK). Taken together, these findings suggest that α- SMA expression in renal interstitial fibroblasts, i.e., myofibroblast transdifferentiation, accelerates the contraction of the tubulointerstitial fibrosis tissue via the Ca2+-dependent pathway, in addition to the pathways involved in fibroblast contraction; this event may lead to renal atrophy and renal failure. |
Autor/es principal/es: | Ina, Keisuke Kitamura, Hirokazu Tatsukawa, Shuji Fujikura, Yoshihisa |
Forma parte de: | Histology and histopathology, Vol. 26, nº 7 (2011) |
URI: | http://hdl.handle.net/10201/49327 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 12 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.26, nº7 (2011) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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Ina-26-855-866-2011.pdf | 5,5 MB | Adobe PDF | Visualizar/Abrir |
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