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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Ina, Keisuke | - |
dc.contributor.author | Kitamura, Hirokazu | - |
dc.contributor.author | Tatsukawa, Shuji | - |
dc.contributor.author | Fujikura, Yoshihisa | - |
dc.date.accessioned | 2016-04-25T18:50:53Z | - |
dc.date.available | 2016-04-25T18:50:53Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1699-5848 | - |
dc.identifier.issn | 0213-3911 | - |
dc.identifier.uri | http://hdl.handle.net/10201/49327 | - |
dc.description.abstract | Myofibroblast transdifferentiation plays a crucial role in the development and progression of renal tubulointerstitial fibrosis. However, the significance of α-smooth muscle actin (α-SMA) expression, which is the major morphological characteristic of myofibroblasts, remains to be determined in detail. The effect of α-SMA expression on fibrosis tissue was examined by using a fibrosis model (collagen gel) in vitro. The transdifferentiation of fibroblasts into myofibroblasts was triggered in the culture medium with 0.5% fetal bovine serum (FBS)+transforming growth factor (TGF)- ß1, but not with 10% FBS+TGF-ß1. The TGF-ß1- induced gel contraction caused by myofibroblasts was greater than that by fibroblasts. Gel contraction by myofibroblasts involved the Ca2+-dependent myosin light chain kinase pathway, as well as the activation of Rho kinase and p38 mitogen-activated protein kinase (MAPK). Taken together, these findings suggest that α- SMA expression in renal interstitial fibroblasts, i.e., myofibroblast transdifferentiation, accelerates the contraction of the tubulointerstitial fibrosis tissue via the Ca2+-dependent pathway, in addition to the pathways involved in fibroblast contraction; this event may lead to renal atrophy and renal failure. | es |
dc.format | application/pdf | es |
dc.format.extent | 12 | es |
dc.language | eng | es |
dc.publisher | F. Hernández y Juan F. Madrid. Murcia: Universidad de Murcia, Departamento de Biología Celular e Histología | es |
dc.relation.ispartof | Histology and histopathology, Vol. 26, nº 7 (2011) | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Renal fibrosis | es |
dc.subject | Myofibroblast | es |
dc.subject.other | 611 - Anatomía | es |
dc.title | Significance of α-SMA in myofibroblasts emerging in renal tubulointerstitial fibrosis | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.26, nº7 (2011) |
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Fichero | Descripción | Tamaño | Formato | |
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Ina-26-855-866-2011.pdf | 5,5 MB | Adobe PDF | Visualizar/Abrir |
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