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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Preusser, Matthias | es |
dc.contributor.author | Birner, P. | es |
dc.contributor.author | Ambros, I.M. | - |
dc.contributor.author | Ambros, P.F. | - |
dc.contributor.author | Budka, H. | - |
dc.contributor.author | Harris, A.L. | - |
dc.contributor.author | Hainfellner, J.A. | - |
dc.date.accessioned | 2011-06-30T12:01:16Z | - |
dc.date.available | 2011-06-30T12:01:16Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 0213-3911 | es |
dc.identifier.uri | http://hdl.handle.net/10201/22553 | - |
dc.description.abstract | Background. Expression of hypoxia-related tissue factors in 1p-aberrant oligodendroglial neoplasms diminishes patient outcome. Differentiated embryochondrocyte expressed gene 1 (DEC1) has been described as novel hypoxia-related tissue factor. In our study, we assessed the expression of DEC1 in 1p aberrant oligodendroglial neoplasms and its association with necrosis and expression of hypoxia-inducible factor 1a (HIF-1a), carbonic anhydrase-9 (CA9), and vascular endothelial growth factor-mRNA (VEGF). Materials and methods. 44 primary and 16 recurrent oligodendroglial neoplasms with 1p-aberrations were investigated immunohistochemically for the expression of DEC1, HIF-1a, and CA9. Expression of VEGF was investigated using in situ hybridization. DEC1 expression was correlated with necrosis and with expression of HIF-1a, CA9, and VEGF. Results. DEC1 was expressed in tumor cell nuclei, and occasionally in nuclei of endothelial cells, and glial and neuronal cells of surrounding brain tissue. High expression (>10% of tumor cells immunolabeled) of DEC1 was found in 56 cases, low expression (<10% of tumor cells immunolabeled) was found in 3 cases. In 1 case no expression of DEC1 was evident. DEC1 expression showed no topographical association with necrosis or expression of HIF-1a, CA9, or VEGF. Conclusion. DEC1 expression is found in the majority of 1p-aberrant oligodendroglial neoplasms and does not correlate with necrosis or expression of HIF-1a, CA9, VEGF. Thus, immunohistochemical analysis of DEC1 expression is in our hands not suitable for detection of tissue hypoxia in this type of primary brain tumor. | es |
dc.format | application/pdf | es |
dc.format.extent | 5 | es |
dc.language | eng | es |
dc.publisher | Murcia : F. Hernández | es |
dc.relation.ispartof | Histology and histopathology | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Oligodendroglioma | es |
dc.subject | Hypoxia | es |
dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología | es |
dc.title | DEC1 expression in 1p-aberrant oligodendroglial neoplasms | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.20, nº 4 (2005) |
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DEC1 expression in 1paberrant.pdf | 2,96 MB | Adobe PDF | Visualizar/Abrir |
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