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Título: COX-2 overexpression in canine tumors: potential therapeutic targets in oncology
Fecha de publicación: 2005
Editorial: Murcia : F. Hernández
ISSN: 0213-3911
Materias relacionadas: CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología
Palabras clave: Canine tumors
Chemotherapy
Resumen: Cyclooxygenases catalyze the initial, ratelimiting steps of prostaglandin synthesis from arachidonic acid. Two isoforms of this enzyme exist in mammalian and avian species: COX-1 and COX-2. COX-1 is constitutively expressed and is the major isoform of gastrointestinal tissue. COX-2 is induced in response to inflammatory stimuli. COX-2 has been implicated in carcinogenesis of several neoplasms. Furthermore, COX-2 over-expression has been noted in many solid tumours and has been correlated with a worse prognosis in colorectal cancer, non-small-cell lung cancer, mesothelioma and gastric cancer. In this review, the most recent findings on the mechanisms by which COX-2 promote tumorigenesis are discussed, with particular emphasis on the studies involving spontaneous canine neoplasms.
Autor/es principal/es: Spugnini, E.P.
Porrello, A.
Citro, G.
Baldi, A.
Forma parte de: Histology and histopathology
URI: http://hdl.handle.net/10201/22547
Tipo de documento: info:eu-repo/semantics/article
Número páginas / Extensión: 4
Derechos: info:eu-repo/semantics/openAccess
Aparece en las colecciones:Vol.20, nº 4 (2005)

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