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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Spugnini, E.P. | es |
dc.contributor.author | Porrello, A. | es |
dc.contributor.author | Citro, G. | - |
dc.contributor.author | Baldi, A. | - |
dc.date.accessioned | 2011-06-30T12:01:12Z | - |
dc.date.available | 2011-06-30T12:01:12Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 0213-3911 | es |
dc.identifier.uri | http://hdl.handle.net/10201/22547 | - |
dc.description.abstract | Cyclooxygenases catalyze the initial, ratelimiting steps of prostaglandin synthesis from arachidonic acid. Two isoforms of this enzyme exist in mammalian and avian species: COX-1 and COX-2. COX-1 is constitutively expressed and is the major isoform of gastrointestinal tissue. COX-2 is induced in response to inflammatory stimuli. COX-2 has been implicated in carcinogenesis of several neoplasms. Furthermore, COX-2 over-expression has been noted in many solid tumours and has been correlated with a worse prognosis in colorectal cancer, non-small-cell lung cancer, mesothelioma and gastric cancer. In this review, the most recent findings on the mechanisms by which COX-2 promote tumorigenesis are discussed, with particular emphasis on the studies involving spontaneous canine neoplasms. | es |
dc.format | application/pdf | es |
dc.format.extent | 4 | es |
dc.language | eng | es |
dc.publisher | Murcia : F. Hernández | es |
dc.relation.ispartof | Histology and histopathology | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Canine tumors | es |
dc.subject | Chemotherapy | es |
dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología | es |
dc.title | COX-2 overexpression in canine tumors: potential therapeutic targets in oncology | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.20, nº 4 (2005) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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COX2 overexpression in canine tumors.pdf | 64,61 kB | Adobe PDF | Visualizar/Abrir |
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