Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10201/21475

Título: Modulatory role of IL10 in endothelial cell damage and platelet adhesion
Fecha de publicación: 2003
Editorial: Murcia : F. Hernández
ISSN: 0213-3911
Materias relacionadas: CDU::6 - Ciencias aplicadas::61 - Medicina
Palabras clave: Endothelial cells
Platelet
Resumen: This study explores the possibility of a regulatory role for cytokine IL-10 in platelet aggregation as an active vascular repair mechanism. Endothelial cells from human umbilical cord vein were cultured in the presence of different IL-10 concentrations (0-100 ng/ml). Platelet-rich plasma was then added to these cultures and allowed to act for 30 minutes. To rule out blood plasma involvement, washed platelets were also incubated with IL-10 (0-100 ng/ml). Changes in endothelial cell morphology were observed depending on the IL-10 concentration used; apoptotic cells appearing at the highest IL-10 concentration. Greatest platelet adhesion was noted at the highest IL-10 concentration. It was concluded that, in this in vitro model, low IL-10 levels do not affect cell viability or the pattern of platelet adhesion, but at high doses, this cytokine induces cell death and enhances platelet deposition.
Autor/es principal/es: Gimeno, M.J.
Pascual, G.
García-Honduvilla, N.
Prieto, A.
Alvarez de Mon, M.
Bellón, J.M.
Buján, J.
Forma parte de: Histology and histopathology
URI: http://hdl.handle.net/10201/21475
Tipo de documento: info:eu-repo/semantics/article
Número páginas / Extensión: 8
Derechos: info:eu-repo/semantics/openAccess
Aparece en las colecciones:Vol.18, nº 3 (2003)

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