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Título: | Modulatory role of IL10 in endothelial cell damage and platelet adhesion |
Fecha de publicación: | 2003 |
Editorial: | Murcia : F. Hernández |
ISSN: | 0213-3911 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina |
Palabras clave: | Endothelial cells Platelet |
Resumen: | This study explores the possibility of a regulatory role for cytokine IL-10 in platelet aggregation as an active vascular repair mechanism. Endothelial cells from human umbilical cord vein were cultured in the presence of different IL-10 concentrations (0-100 ng/ml). Platelet-rich plasma was then added to these cultures and allowed to act for 30 minutes. To rule out blood plasma involvement, washed platelets were also incubated with IL-10 (0-100 ng/ml). Changes in endothelial cell morphology were observed depending on the IL-10 concentration used; apoptotic cells appearing at the highest IL-10 concentration. Greatest platelet adhesion was noted at the highest IL-10 concentration. It was concluded that, in this in vitro model, low IL-10 levels do not affect cell viability or the pattern of platelet adhesion, but at high doses, this cytokine induces cell death and enhances platelet deposition. |
Autor/es principal/es: | Gimeno, M.J. Pascual, G. García-Honduvilla, N. Prieto, A. Alvarez de Mon, M. Bellón, J.M. Buján, J. |
Forma parte de: | Histology and histopathology |
URI: | http://hdl.handle.net/10201/21475 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 8 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.18, nº 3 (2003) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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Modulatory role of IL10 in endothelial.pdf | 3,64 MB | Adobe PDF | Visualizar/Abrir |
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