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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Gimeno, M.J. | es |
dc.contributor.author | Pascual, G. | es |
dc.contributor.author | García-Honduvilla, N. | - |
dc.contributor.author | Prieto, A. | - |
dc.contributor.author | Alvarez de Mon, M. | - |
dc.contributor.author | Bellón, J.M. | - |
dc.contributor.author | Buján, J. | - |
dc.date.accessioned | 2011-06-08T09:03:46Z | - |
dc.date.available | 2011-06-08T09:03:46Z | - |
dc.date.issued | 2003 | - |
dc.identifier.issn | 0213-3911 | es |
dc.identifier.uri | http://hdl.handle.net/10201/21475 | - |
dc.description.abstract | This study explores the possibility of a regulatory role for cytokine IL-10 in platelet aggregation as an active vascular repair mechanism. Endothelial cells from human umbilical cord vein were cultured in the presence of different IL-10 concentrations (0-100 ng/ml). Platelet-rich plasma was then added to these cultures and allowed to act for 30 minutes. To rule out blood plasma involvement, washed platelets were also incubated with IL-10 (0-100 ng/ml). Changes in endothelial cell morphology were observed depending on the IL-10 concentration used; apoptotic cells appearing at the highest IL-10 concentration. Greatest platelet adhesion was noted at the highest IL-10 concentration. It was concluded that, in this in vitro model, low IL-10 levels do not affect cell viability or the pattern of platelet adhesion, but at high doses, this cytokine induces cell death and enhances platelet deposition. | es |
dc.format | application/pdf | es |
dc.format.extent | 8 | es |
dc.language | eng | es |
dc.publisher | Murcia : F. Hernández | es |
dc.relation.ispartof | Histology and histopathology | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Endothelial cells | es |
dc.subject | Platelet | es |
dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina | es |
dc.title | Modulatory role of IL10 in endothelial cell damage and platelet adhesion | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.18, nº 3 (2003) |
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Fichero | Descripción | Tamaño | Formato | |
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Modulatory role of IL10 in endothelial.pdf | 3,64 MB | Adobe PDF | Visualizar/Abrir |
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