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Título: | Expression of hypoxia-inducible factor-1a (HIF-1a) in pituitary tumours |
Fecha de publicación: | 2003 |
Editorial: | Murcia : F. Hernández |
ISSN: | 0213-3911 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología::616.2 - Patología del aparato respiratorio |
Palabras clave: | Angiogenesis Pituitary tumors |
Resumen: | The present study was performed to investigate HIF-1a (hypoxia-inducible factor-1a) expression in a large number of immunohistochemically and ultrastructurally characterized surgically removed pituitary tumours. The potential relation of HIF-1a with outcome variables as well as the presence of HIF-1a expression in the tumours treated with dopamine agonists and octreotide, a long-acting somatostatin analogue was also investigated. HIF-1a immunoreactivity was confined to the nucleoplasm whereas the nucleoli were unconspicuous. The distribution of HIF-1a was evident in the tumours whereas normal adenohypophysial cells showed no HIF- 1a staining. HIF-1a expression was detected not only in the tumour cells but also in endothelial cells lining the blood vessels within the tumour. ACTH producing adenomas showed the lowest level of HIF-1a expression whereas pituitary carcinomas and GH producing adenomas had the highest counts. The statistical study demonstrated no significant correlation between HIF-1a expression, patient age, gender, tumour, size, invasiveness, cell proliferation rate and vascularity. These results suggest that the behaviour of pituitary tumours does not primarily depend of HIF-1a expression. Our study demonstrated an increase HIF-1a expression in bromocriptine treated PRL producing pituitary adenomas compared with untreated tumours but no increase in octreotide treated tumours. |
Autor/es principal/es: | Vidal, S. Horvath, E. Kovacs, K. Kuroki, T. Lloyd, R.V. Scheithauer, B.W. |
Forma parte de: | Histology and histopathology |
URI: | http://hdl.handle.net/10201/21454 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 8 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.18, nº 3 (2003) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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Expression of hypoxiainducible.pdf | 232,36 kB | Adobe PDF | Visualizar/Abrir |
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