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http://hdl.handle.net/10201/21454
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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Vidal, S. | es |
dc.contributor.author | Horvath, E. | es |
dc.contributor.author | Kovacs, K. | - |
dc.contributor.author | Kuroki, T. | - |
dc.contributor.author | Lloyd, R.V. | - |
dc.contributor.author | Scheithauer, B.W. | - |
dc.date.accessioned | 2011-06-08T09:03:26Z | - |
dc.date.available | 2011-06-08T09:03:26Z | - |
dc.date.issued | 2003 | - |
dc.identifier.issn | 0213-3911 | es |
dc.identifier.uri | http://hdl.handle.net/10201/21454 | - |
dc.description.abstract | The present study was performed to investigate HIF-1a (hypoxia-inducible factor-1a) expression in a large number of immunohistochemically and ultrastructurally characterized surgically removed pituitary tumours. The potential relation of HIF-1a with outcome variables as well as the presence of HIF-1a expression in the tumours treated with dopamine agonists and octreotide, a long-acting somatostatin analogue was also investigated. HIF-1a immunoreactivity was confined to the nucleoplasm whereas the nucleoli were unconspicuous. The distribution of HIF-1a was evident in the tumours whereas normal adenohypophysial cells showed no HIF- 1a staining. HIF-1a expression was detected not only in the tumour cells but also in endothelial cells lining the blood vessels within the tumour. ACTH producing adenomas showed the lowest level of HIF-1a expression whereas pituitary carcinomas and GH producing adenomas had the highest counts. The statistical study demonstrated no significant correlation between HIF-1a expression, patient age, gender, tumour, size, invasiveness, cell proliferation rate and vascularity. These results suggest that the behaviour of pituitary tumours does not primarily depend of HIF-1a expression. Our study demonstrated an increase HIF-1a expression in bromocriptine treated PRL producing pituitary adenomas compared with untreated tumours but no increase in octreotide treated tumours. | es |
dc.format | application/pdf | es |
dc.format.extent | 8 | es |
dc.language | eng | es |
dc.publisher | Murcia : F. Hernández | es |
dc.relation.ispartof | Histology and histopathology | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Angiogenesis | es |
dc.subject | Pituitary tumors | es |
dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología::616.2 - Patología del aparato respiratorio | es |
dc.title | Expression of hypoxia-inducible factor-1a (HIF-1a) in pituitary tumours | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.18, nº 3 (2003) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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Expression of hypoxiainducible.pdf | 232,36 kB | Adobe PDF | ![]() Visualizar/Abrir |
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