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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Doi, Y. | es |
dc.contributor.author | Kudo, H. | es |
dc.contributor.author | Nishino, T. | - |
dc.contributor.author | Yamamoto, O. | - |
dc.contributor.author | Nagata, T. | - |
dc.contributor.author | Nara, S. | - |
dc.contributor.author | Morita, M. | - |
dc.contributor.author | Fujimoto, S. | - |
dc.date.accessioned | 2011-05-11T10:57:47Z | - |
dc.date.available | 2011-05-11T10:57:47Z | - |
dc.date.issued | 2002 | - |
dc.identifier.issn | 0213-3911 | es |
dc.identifier.uri | http://hdl.handle.net/10201/20764 | - |
dc.description.abstract | Deeply anesthetized male Wistar rats were perfused by Hanks’ balanced salt solution bubbled with either 95%air and 5%CO2 (normoxic group) or 95%N2 and 5%CO2 (hypoxic group) from the thoracic aorta for 30 min, and the isolated abdominal aortae from both groups were used for electron microscopy, immunocytochemistry of endothelin (ET)-1 and ETconverting enzyme (ECE)-1, and in situ hybridization of p r e p r o E T-1 mRNA. A remarkable increase in the number of Weibel-Palade (WP) bodies, storage sites of E T-1 and ECE-1, occurred in the hypoxic group when compared to the normoxic group. Immunoreactivities for E T-1 and ECE-1, and signals for preproET-1 mRNA were seen along the endothelia of both groups, but the intensities were significantly elevated in the hypoxic group. The increase in the number of ECE-1 immunoreactive gold particles was noticed especially in WP bodies in the hypoxic group. These findings indicate the enhancement of preproET-1 synthesis in the aortic endothelial cells as well as the acceleration of ET- 1 processing in increased WP bodies in such cells in an experimentally hypoxic condition of the rat aortae. | es |
dc.format | application/pdf | es |
dc.format.extent | 9 | es |
dc.language | eng | es |
dc.publisher | Murcia : F. Hernández | es |
dc.relation.ispartof | Histology and histopathology | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Hypoxia | es |
dc.subject | Rat aorta | es |
dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina | es |
dc.title | Enhanced expression of endothelin-1 and endothelinconverting enzyme-1 in acute hypoxic rat aorta | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.17, nº 1 (2002) |
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Enhanced expression of endothelin1 and endothelinconverting.pdf | 2,23 MB | Adobe PDF | Visualizar/Abrir |
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