Please use this identifier to cite or link to this item:

Full metadata record
DC FieldValueLanguage
dc.contributor.authorNishino, T.-
dc.contributor.authorYamamoto, O.-
dc.contributor.authorNagata, T.-
dc.contributor.authorNara, S.-
dc.contributor.authorMorita, M.-
dc.contributor.authorFujimoto, S.-
dc.description.abstractDeeply anesthetized male Wistar rats were perfused by Hanks’ balanced salt solution bubbled with either 95%air and 5%CO2 (normoxic group) or 95%N2 and 5%CO2 (hypoxic group) from the thoracic aorta for 30 min, and the isolated abdominal aortae from both groups were used for electron microscopy, immunocytochemistry of endothelin (ET)-1 and ETconverting enzyme (ECE)-1, and in situ hybridization of p r e p r o E T-1 mRNA. A remarkable increase in the number of Weibel-Palade (WP) bodies, storage sites of E T-1 and ECE-1, occurred in the hypoxic group when compared to the normoxic group. Immunoreactivities for E T-1 and ECE-1, and signals for preproET-1 mRNA were seen along the endothelia of both groups, but the intensities were significantly elevated in the hypoxic group. The increase in the number of ECE-1 immunoreactive gold particles was noticed especially in WP bodies in the hypoxic group. These findings indicate the enhancement of preproET-1 synthesis in the aortic endothelial cells as well as the acceleration of ET- 1 processing in increased WP bodies in such cells in an experimentally hypoxic condition of the rat
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.subjectRat aortaes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleEnhanced expression of endothelin-1 and endothelinconverting enzyme-1 in acute hypoxic rat aortaes
Appears in Collections:Vol.17, nº 1 (2002)

Files in This Item:
File Description SizeFormat 
Enhanced expression of endothelin1 and endothelinconverting.pdf2,23 MBAdobe PDFThumbnail

Items in Digitum are protected by copyright, with all rights reserved, unless otherwise indicated.