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Título: | Selective expression of lysyl oxidase (LOX) in the stromal reactions of broncho-pulmonary carcinomas |
Fecha de publicación: | 2000 |
Editorial: | Murcia : F. Hernández |
ISSN: | 0213-3911 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología::616.2 - Patología del aparato respiratorio |
Palabras clave: | Bronchopulmonary carcinoma Myofibroblasts |
Resumen: | Lysyl oxidase (LOX) is the extracellular enzyme that initiates the main pathway of collagen and elastin cross-linking. LOX has also been correlated with the ras recision gene, a putative tumour suppressor isolated from revertants of ras-transformed fibroblasts. The present study investigates the potential correlation of LOX-dependent matrix protein cross-linking in the stromal reaction of lung carcinomas, with reference to the architecture of the main stromal reactions accompanying the neoplastic breast tissues. A strong LOX expression was associated with the hypertrophic scar-like stromal reaction found at the front of tumour progression in squamous carcinomas, adenocarcinomas, large cell carcinomas, or at sites of initial extense in bronchiolo-alveolar carcinomas. In contrast, little or no LOX expression was found within the stromal reaction of invasive carcinomas, small cell carcinomas, and neuro-endocrine carcinomas. The significance of LOX expression and of the stromal reaction are discussed, in light of data that associate LOX expression with tumours displaying a rather good prognosis. |
Autor/es principal/es: | peyrol, S. Galateau-Salle, F. Raccurt, M. Gleyzal, C. Sommer, P. |
Forma parte de: | Histology and histopathology |
URI: | http://hdl.handle.net/10201/19371 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 9 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.15, nº 4 (2000) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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lSelective expression of lysyl oxidase LOX in the stromal reactions of bronchopulmonary carcinomas.pdf | 7,01 MB | Adobe PDF | Visualizar/Abrir |
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