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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | peyrol, S. | es |
dc.contributor.author | Galateau-Salle, F. | es |
dc.contributor.author | Raccurt, M. | - |
dc.contributor.author | Gleyzal, C. | - |
dc.contributor.author | Sommer, P. | - |
dc.date.accessioned | 2011-02-22T11:22:46Z | - |
dc.date.available | 2011-02-22T11:22:46Z | - |
dc.date.issued | 2000 | - |
dc.identifier.issn | 0213-3911 | es |
dc.identifier.uri | http://hdl.handle.net/10201/19371 | - |
dc.description.abstract | Lysyl oxidase (LOX) is the extracellular enzyme that initiates the main pathway of collagen and elastin cross-linking. LOX has also been correlated with the ras recision gene, a putative tumour suppressor isolated from revertants of ras-transformed fibroblasts. The present study investigates the potential correlation of LOX-dependent matrix protein cross-linking in the stromal reaction of lung carcinomas, with reference to the architecture of the main stromal reactions accompanying the neoplastic breast tissues. A strong LOX expression was associated with the hypertrophic scar-like stromal reaction found at the front of tumour progression in squamous carcinomas, adenocarcinomas, large cell carcinomas, or at sites of initial extense in bronchiolo-alveolar carcinomas. In contrast, little or no LOX expression was found within the stromal reaction of invasive carcinomas, small cell carcinomas, and neuro-endocrine carcinomas. The significance of LOX expression and of the stromal reaction are discussed, in light of data that associate LOX expression with tumours displaying a rather good prognosis. | es |
dc.format | application/pdf | es |
dc.format.extent | 9 | es |
dc.language | eng | es |
dc.publisher | Murcia : F. Hernández | es |
dc.relation.ispartof | Histology and histopathology | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Bronchopulmonary carcinoma | es |
dc.subject | Myofibroblasts | es |
dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología::616.2 - Patología del aparato respiratorio | es |
dc.title | Selective expression of lysyl oxidase (LOX) in the stromal reactions of broncho-pulmonary carcinomas | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.15, nº 4 (2000) |
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Fichero | Descripción | Tamaño | Formato | |
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lSelective expression of lysyl oxidase LOX in the stromal reactions of bronchopulmonary carcinomas.pdf | 7,01 MB | Adobe PDF | Visualizar/Abrir |
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