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Título: | Proteinase-antiproteinase imbalance in the pathogenesis of Emphysema: The role of metalloproteinases in lung damage |
Fecha de publicación: | 1999 |
Editorial: | Murcia : F. Hernández |
ISSN: | 0213-3911 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología::616.2 - Patología del aparato respiratorio |
Palabras clave: | Pulmonary emphysema Collagenase |
Resumen: | Pulmonary emphysema refers to a lung disorder characterized by a diffuse destruction of the alveolar walls resulting in enlargement of the distal airspaces. The disease is usually a chronic, progressive, and disabling disorder. The concept of proteinaselantiproteinase imbalance evolved from the identification of patients with al-antytripsin deficiency, and from the development of experimental emphysematous lesions using different enzymes. For a long time, this concept was seen as an elastase/antielastase imbalance, with the consequent degradation of elastin. Recent evidence, however, suggests that an intricate process of pulmonary remodeling occurs during the development of emphysema, where a complex network of serine proteases and metalloproteinases capable of degrading different extracellular matrix molecules, primarily, but not exclusively fibrillar collagens and elastin, are implicated in the pathogenesis of this disease. |
Autor/es principal/es: | Pardo, A. Selman, M. |
Forma parte de: | Histology and histopathology |
URI: | http://hdl.handle.net/10201/19147 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 7 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.14, nº 1 (1999) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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Proteinaseantiproteinase imbalance in the pathogenesis of Emphysema. The role of metalloproteinases in lung damage.pdf | 408,81 kB | Adobe PDF | Visualizar/Abrir |
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