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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Pardo, A. | es |
dc.contributor.author | Selman, M. | es |
dc.date.accessioned | 2011-02-22T11:07:43Z | - |
dc.date.available | 2011-02-22T11:07:43Z | - |
dc.date.issued | 1999 | - |
dc.identifier.issn | 0213-3911 | es |
dc.identifier.uri | http://hdl.handle.net/10201/19147 | - |
dc.description.abstract | Pulmonary emphysema refers to a lung disorder characterized by a diffuse destruction of the alveolar walls resulting in enlargement of the distal airspaces. The disease is usually a chronic, progressive, and disabling disorder. The concept of proteinaselantiproteinase imbalance evolved from the identification of patients with al-antytripsin deficiency, and from the development of experimental emphysematous lesions using different enzymes. For a long time, this concept was seen as an elastase/antielastase imbalance, with the consequent degradation of elastin. Recent evidence, however, suggests that an intricate process of pulmonary remodeling occurs during the development of emphysema, where a complex network of serine proteases and metalloproteinases capable of degrading different extracellular matrix molecules, primarily, but not exclusively fibrillar collagens and elastin, are implicated in the pathogenesis of this disease. | es |
dc.format | application/pdf | es |
dc.format.extent | 7 | es |
dc.language | eng | es |
dc.publisher | Murcia : F. Hernández | es |
dc.relation.ispartof | Histology and histopathology | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Pulmonary emphysema | es |
dc.subject | Collagenase | es |
dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología::616.2 - Patología del aparato respiratorio | es |
dc.title | Proteinase-antiproteinase imbalance in the pathogenesis of Emphysema: The role of metalloproteinases in lung damage | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.14, nº 1 (1999) |
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Proteinaseantiproteinase imbalance in the pathogenesis of Emphysema. The role of metalloproteinases in lung damage.pdf | 408,81 kB | Adobe PDF | Visualizar/Abrir |
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