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Título: | Chemocytoarchitecture of the rat locus ceruleus |
Fecha de publicación: | 1993 |
Editorial: | Murcia : F. Hernández |
ISSN: | 0213-3911 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina |
Palabras clave: | Locus ceruleus Immunocytochemistry |
Resumen: | I shall elaborate on the cytochemical classifications of the rat locus ceruleus (LC) and state how each of these could be identified. In the LC, 80% ( 1,30911,642) of the noradrenergic (NA) neurons are also GABAergic. This is found by demonstrating that two immunoreactivities coexist in adjacent sections alternately immunostained by anti-TH or anti-GABA antibody. Pharmacological manipulations with pargyline (75 mglkg, i.p., 2 h prior to perfusion) and L-tryptophan (1 50 mglkg, 1.5 h prior to perfusion) revealed 5-HT-like immunoreactivity (5-HT-LI) in most LC cells (masked 5-HT cells) that produce 5-HT but not other indoleamines. If 5-HTP is applied instead of tryptophan, 5-HT-L1 is shown by the raphe nuclei and a few LC cells (masked indoleamine cells) in the marginal zone. Anti- GAD antibody reveals GAD-L1 in 32% of GABA neurons predominantly in the dorsal division. In situ hybridization studies detected tryptophan hydroxylase mRNA and GAD mRNA in many small- and mediumsized neurons. It is concluded that the LC consists mostly of an NA population that is possibly synthesizing multiple transmitters, such as GABA, GAD and 5-HT in single neurons so that the system enables the LC simultaneously to innervate the entire CNS. |
Autor/es principal/es: | Lijima, K. |
Forma parte de: | Histology and histopathology |
URI: | http://hdl.handle.net/10201/18434 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 11 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol. 8, nº 3 (1993) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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Chemocytoarchitecture of the rat locus ceruleus.pdf | 6,1 MB | Adobe PDF | Visualizar/Abrir |
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