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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Lijima, K. | es |
dc.date.accessioned | 2011-02-01T09:17:03Z | - |
dc.date.available | 2011-02-01T09:17:03Z | - |
dc.date.issued | 1993 | - |
dc.identifier.issn | 0213-3911 | es |
dc.identifier.uri | http://hdl.handle.net/10201/18434 | - |
dc.description.abstract | I shall elaborate on the cytochemical classifications of the rat locus ceruleus (LC) and state how each of these could be identified. In the LC, 80% ( 1,30911,642) of the noradrenergic (NA) neurons are also GABAergic. This is found by demonstrating that two immunoreactivities coexist in adjacent sections alternately immunostained by anti-TH or anti-GABA antibody. Pharmacological manipulations with pargyline (75 mglkg, i.p., 2 h prior to perfusion) and L-tryptophan (1 50 mglkg, 1.5 h prior to perfusion) revealed 5-HT-like immunoreactivity (5-HT-LI) in most LC cells (masked 5-HT cells) that produce 5-HT but not other indoleamines. If 5-HTP is applied instead of tryptophan, 5-HT-L1 is shown by the raphe nuclei and a few LC cells (masked indoleamine cells) in the marginal zone. Anti- GAD antibody reveals GAD-L1 in 32% of GABA neurons predominantly in the dorsal division. In situ hybridization studies detected tryptophan hydroxylase mRNA and GAD mRNA in many small- and mediumsized neurons. It is concluded that the LC consists mostly of an NA population that is possibly synthesizing multiple transmitters, such as GABA, GAD and 5-HT in single neurons so that the system enables the LC simultaneously to innervate the entire CNS. | es |
dc.format | application/pdf | es |
dc.format.extent | 11 | es |
dc.language | eng | es |
dc.publisher | Murcia : F. Hernández | es |
dc.relation.ispartof | Histology and histopathology | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Locus ceruleus | es |
dc.subject | Immunocytochemistry | es |
dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina | es |
dc.title | Chemocytoarchitecture of the rat locus ceruleus | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol. 8, nº 3 (1993) |
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Chemocytoarchitecture of the rat locus ceruleus.pdf | 6,1 MB | Adobe PDF | Visualizar/Abrir |
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