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Título: | Effects of 4-aminopyrazolo (3,4-d) pyrimidine on rat hepatocytes: an ultrastructural morphometric study |
Fecha de publicación: | 1989 |
Editorial: | Murcia : F. Hernández |
ISSN: | 0213-3911 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina |
Palabras clave: | Liver, Cholesterol metabolism |
Resumen: | Summary. The prolonged administration of the hypolipidemic drug 4-aminopyrazolo (3,4-d) pyrimidine (4APP) induced conspicuous morphological changes in rat hepatocytes, which are clearly demonstrated by stereology. We observed a significant decrease in the rough endoplamic reticulum, and an accumulation of lipid droplets, which was coupled with a comparable rise in the hepatic concentrations of total cholesterol and triglycerides. These changes were interpreted as the expression of the 4APP-provoked impairment of the synthesis of the polypeptide chains of lipoproteins and of the consequent suppression of the assembly of lipid molecules in exportable lipoproteins. We also noted a neto lowering in smooth endoplasmic reticulum and perxisomes, a decrease which was hypothesized to be the morphological counterpart of a reduced de novo cholesterol synthesis, due to the 4APP-induced rise in the intracellular cholesterol concentration. |
Autor/es principal/es: | Belloni, A. S. Rebuffat, P. Mazzocchi, G. Meneghelli, V. Nussdorfer, G.G. |
URI: | http://hdl.handle.net/10201/17960 |
Tipo de documento: | info:eu-repo/semantics/article |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol. 4, nº 1 (1989) |
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Effects of 4-aminopyrazolo (3,4-d) pyrimidine on rat hepatocytes, an ultrastructural morphometric study.pdf | 680,27 kB | Adobe PDF | Visualizar/Abrir |
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