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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Belloni, A. S. | - |
dc.contributor.author | Rebuffat, P. | - |
dc.contributor.author | Mazzocchi, G. | - |
dc.contributor.author | Meneghelli, V. | - |
dc.contributor.author | Nussdorfer, G.G. | - |
dc.date.accessioned | 2011-01-18T09:27:26Z | - |
dc.date.available | 2011-01-18T09:27:26Z | - |
dc.date.issued | 1989 | - |
dc.identifier.issn | 0213-3911 | - |
dc.identifier.uri | http://hdl.handle.net/10201/17960 | - |
dc.description.abstract | Summary. The prolonged administration of the hypolipidemic drug 4-aminopyrazolo (3,4-d) pyrimidine (4APP) induced conspicuous morphological changes in rat hepatocytes, which are clearly demonstrated by stereology. We observed a significant decrease in the rough endoplamic reticulum, and an accumulation of lipid droplets, which was coupled with a comparable rise in the hepatic concentrations of total cholesterol and triglycerides. These changes were interpreted as the expression of the 4APP-provoked impairment of the synthesis of the polypeptide chains of lipoproteins and of the consequent suppression of the assembly of lipid molecules in exportable lipoproteins. We also noted a neto lowering in smooth endoplasmic reticulum and perxisomes, a decrease which was hypothesized to be the morphological counterpart of a reduced de novo cholesterol synthesis, due to the 4APP-induced rise in the intracellular cholesterol concentration. | es |
dc.format | application/pdf | es |
dc.language | eng | es |
dc.publisher | Murcia : F. Hernández | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Liver, Cholesterol metabolism | es |
dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina | es |
dc.title | Effects of 4-aminopyrazolo (3,4-d) pyrimidine on rat hepatocytes: an ultrastructural morphometric study | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol. 4, nº 1 (1989) |
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Effects of 4-aminopyrazolo (3,4-d) pyrimidine on rat hepatocytes, an ultrastructural morphometric study.pdf | 680,27 kB | Adobe PDF | Visualizar/Abrir |
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