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10.1016/j.anireprosci.2024.107476
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Rodríguez-Martínez, Heriberto | - |
dc.contributor.author | Martínez Serrano, Cristina A. | - |
dc.contributor.author | Álvarez-Rodríguez, Manuel | - |
dc.contributor.author | Martínez, Emilio A. | - |
dc.contributor.author | Roca, Jordi | - |
dc.contributor.other | Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Medicina y Cirugía Animal | es |
dc.date.accessioned | 2024-09-05T09:51:25Z | - |
dc.date.available | 2024-09-05T09:51:25Z | - |
dc.date.issued | 2024-04-18 | - |
dc.identifier.citation | Anim Reprod Sci :107476. | es |
dc.identifier.issn | 1873-2232 | - |
dc.identifier.uri | http://hdl.handle.net/10201/143620 | - |
dc.description.abstract | Despite decades of research and handling of semen for use in artificial insemination (AI) and other assisted reproductive technologies, 5-10% of selected boar sires are still considered sub-fertile, escaping current assessment methods for sperm quality and resilience to preservation. As end-product, the ejaculate (emitted spermatozoa sequentially exposed to the composite seminal plasma, the SP) ought to define the homeostasis of the testes, the epididymis, and the accessory sexual glands. Yet, linking findings in the ejaculate to sperm production biology and fertility is suboptimal. The present essay critically reviews how the ejaculate of a fertile boar can help us to diagnose both reproductive health and resilience to semen handling, focusing on methods -available and under development- to identify suitable biomarkers for cryotolerance and fertility. Bulk SP, semen proteins and microRNAs (miRNAs) have, albeit linked to sperm function and fertility after AI, failed to enhance reproductive outcomes at commercial level, perhaps for just being components of a complex functional pathway. Hence, focus is now on the interaction sperm-SP, comparing in vivo with ex vivo, and regarding nano-sized lipid bilayer seminal extracellular vesicles (sEVs) as priority. sEVs transport fragile molecules (lipids, proteins, nucleic acids) which, shielded from degradation, mediate cell-to-cell communication with spermatozoa and the female internal genital tract. Such interaction modulates essential reproductive processes, from sperm homeostasis to immunological female tolerance. sEVs can be harvested, characterized, stored, and manipulated, e.g. can be used for andrological diagnosis, selection of breeders, and alternatively be used as additives to improve cryosurvival and fertility. | es |
dc.format | application/pdf | es |
dc.format.extent | 18 | es |
dc.language | eng | es |
dc.relation | The research of the authors was funded by the Research Council FORMAS, Stockholm (Grant 2019-00288), the Spanish Ministry of Science and Innovation, Madrid, Spain (MCIN/AEI/10.13039/501100011033): grants PID2020-113493RB-I00; PID2019-108320RJI00; RYC2020-028615-I; PID2022-136561OB-I00; and PID2022-137645OB-I00, FEDER funds (EU), and grant 21935/PI/22 of the Seneca Foundation, Murcia, Spain. | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Sperm production Maturation Ejaculate Diagnostics Fertility biomarkers Pig | es |
dc.title | Reproductive physiology of the boar: What defines the potential fertility of an ejaculate? | es |
dc.type | info:eu-repo/semantics/article | es |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S0378432024000678?via%3Dihub | es |
dc.identifier.doi | 10.1016/j.anireprosci.2024.107476 | - |
Aparece en las colecciones: | Artículos: Medicina y Cirugía Animal |
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1-s2.0-S0378432024000678-main.pdf | 6,63 MB | Adobe PDF | ![]() Visualizar/Abrir |
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