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Título: | COX-2 overexpression in canine tumors: potential therapeutic targets in oncology |
Fecha de publicación: | 2005 |
Editorial: | Murcia : F. Hernández |
ISSN: | 0213-3911 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología |
Palabras clave: | Canine tumors Chemotherapy |
Resumen: | Cyclooxygenases catalyze the initial, ratelimiting steps of prostaglandin synthesis from arachidonic acid. Two isoforms of this enzyme exist in mammalian and avian species: COX-1 and COX-2. COX-1 is constitutively expressed and is the major isoform of gastrointestinal tissue. COX-2 is induced in response to inflammatory stimuli. COX-2 has been implicated in carcinogenesis of several neoplasms. Furthermore, COX-2 over-expression has been noted in many solid tumours and has been correlated with a worse prognosis in colorectal cancer, non-small-cell lung cancer, mesothelioma and gastric cancer. In this review, the most recent findings on the mechanisms by which COX-2 promote tumorigenesis are discussed, with particular emphasis on the studies involving spontaneous canine neoplasms. |
Autor/es principal/es: | Spugnini, E.P. Porrello, A. Citro, G. Baldi, A. |
Forma parte de: | Histology and histopathology |
URI: | http://hdl.handle.net/10201/22547 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 4 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.20, nº 4 (2005) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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COX2 overexpression in canine tumors.pdf | 64,61 kB | Adobe PDF | Visualizar/Abrir |
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