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Título: | Expression of E-cadherin-catenin complex in human benign schwannomas |
Fecha de publicación: | 2002 |
Editorial: | Murcia : F. Hernández |
ISSN: | 0213-3911 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina |
Palabras clave: | Brain tumor Immunohistochemistry |
Resumen: | The Ca2+-dependent cell adhesion molecule E-cadherin has been known to express in normal and reactive Schwann cells in rodents, and to play an important role in Schwann cell-Schwann cell adhesion and maintenance of peripheral nervous tissue architecture. However, little is known about expression of E-cadherin in schwannomas. The aim of the present study was to investigate the cellular expression and localization of E-cadherin, and its associated protein, alpha E-, alpha N- and beta-catenins in human schwannomas, which are supposed to derive from Schwann cells. We tested the hypothesis that these proteins might show an altered expression/distribution in schwannoma cells which correlates with their neoplastic behavior, including sparse cell-cell contact, as seen those in meningiomas and various carcinomas. In human schwannomas, however, E-cadherin, alpha E-catenin, and beta-catenin were detected by western blotting and i m m u n o h i s t o c h e m i s t r y, whereas alpha N-catenin was not. Immunoprecipitation using anti-E-cadherin antibody resulted in alpha E-catenin forming a complex with Ecadherin. SSCP analysis revealed no mutations in the transmembrane domain or in intracellular cateninbinding site of E-cadherin. These data suggest that the Ecadherin- alpha E-catenin complex is well preserved in human schwannoma cells, which is compatible with its benign behavior, and these molecules might be used as additional cell markers of Schwann cell-derived tumors. |
Autor/es principal/es: | Hasegawa, M. Muramatsu, N. Tohma, Y. Fukaya, K. Fujisawa, H. Hayashi, Yoshihiro Tachibana, Osamu Kida, S. Yamashita, J. Saito, K. |
Forma parte de: | Histology and histopathology |
URI: | http://hdl.handle.net/10201/20745 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 6 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.17, nº 1 (2002) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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Expression of Ecadherincatenin complex in human benign schwannomas.pdf | 1,31 MB | Adobe PDF | Visualizar/Abrir |
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