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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Hasegawa, M. | es |
dc.contributor.author | Muramatsu, N. | es |
dc.contributor.author | Tohma, Y. | - |
dc.contributor.author | Fukaya, K. | - |
dc.contributor.author | Fujisawa, H. | - |
dc.contributor.author | Hayashi, Yoshihiro | - |
dc.contributor.author | Tachibana, Osamu | - |
dc.contributor.author | Kida, S. | - |
dc.contributor.author | Yamashita, J. | - |
dc.contributor.author | Saito, K. | - |
dc.date.accessioned | 2011-05-11T10:57:32Z | - |
dc.date.available | 2011-05-11T10:57:32Z | - |
dc.date.issued | 2002 | - |
dc.identifier.issn | 0213-3911 | es |
dc.identifier.uri | http://hdl.handle.net/10201/20745 | - |
dc.description.abstract | The Ca2+-dependent cell adhesion molecule E-cadherin has been known to express in normal and reactive Schwann cells in rodents, and to play an important role in Schwann cell-Schwann cell adhesion and maintenance of peripheral nervous tissue architecture. However, little is known about expression of E-cadherin in schwannomas. The aim of the present study was to investigate the cellular expression and localization of E-cadherin, and its associated protein, alpha E-, alpha N- and beta-catenins in human schwannomas, which are supposed to derive from Schwann cells. We tested the hypothesis that these proteins might show an altered expression/distribution in schwannoma cells which correlates with their neoplastic behavior, including sparse cell-cell contact, as seen those in meningiomas and various carcinomas. In human schwannomas, however, E-cadherin, alpha E-catenin, and beta-catenin were detected by western blotting and i m m u n o h i s t o c h e m i s t r y, whereas alpha N-catenin was not. Immunoprecipitation using anti-E-cadherin antibody resulted in alpha E-catenin forming a complex with Ecadherin. SSCP analysis revealed no mutations in the transmembrane domain or in intracellular cateninbinding site of E-cadherin. These data suggest that the Ecadherin- alpha E-catenin complex is well preserved in human schwannoma cells, which is compatible with its benign behavior, and these molecules might be used as additional cell markers of Schwann cell-derived tumors. | es |
dc.format | application/pdf | es |
dc.format.extent | 6 | es |
dc.language | eng | es |
dc.publisher | Murcia : F. Hernández | es |
dc.relation.ispartof | Histology and histopathology | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Brain tumor | es |
dc.subject | Immunohistochemistry | es |
dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina | es |
dc.title | Expression of E-cadherin-catenin complex in human benign schwannomas | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.17, nº 1 (2002) |
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Expression of Ecadherincatenin complex in human benign schwannomas.pdf | 1,31 MB | Adobe PDF | Visualizar/Abrir |
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