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https://doi.org/10.1016/j.molimm.2007.10.044
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Título: | Regulation of NFAT by poly(ADP-ribose) polymerase activity in T cells |
Fecha de publicación: | 31-oct-2007 |
Editorial: | Elsevier |
Cita bibliográfica: | Molecular Immunology 45 (2008) 1863–1871 |
ISSN: | Print: 0161-5890 |
Palabras clave: | NFAT Nuclear retention Poly-ADP ribose polymerases Poly(ADP-ribosyl)ation |
Resumen: | The nuclear factor of activated T cells (NFAT) family of transcription factors is pivotal for T lymphocyte functionality. All relevant NFAT activation events upon T cells stimulation such as nuclear translocation, DNA binding, and transcriptional activity have been shown to be dictated by its phosphorylation state. Here, we provide evidence for a novel post- translational modification that regulates NFAT. Indeed, NFATc1 and NFATc2 are poly(ADP-ribosyl)ated by poly-ADP-ribose polymerase-1 (PARP-1). Moreover, we have also found a physical interaction between PARP-1 and both NFATc1 and NFATc2. Interestingly, PARP is activated during T cell stimulation in the absence of DNA damage, leading to ADP-ribose polymers formation and transfer to nuclear acceptor proteins. Our data suggest that poly(ADP-ribosyl)ation modulates the activation of NFAT in T cells, as PARP inhibition causes an increase in NFAT-dependent transactivation and a delay in NFAT nuclear export. Poly(ADPribosyl)ation will expedited NFAT export from the nucleus directly or by priming/facilitating NFAT phosphorylation. Altogether, these data point to PARP-1 and poly(ADP-ribosyl)ation as a novel regulatory mechanism of NFAT at nuclear level, suggesting a potential use of PARP as a new therapeutic target in the modulation of NFAT. |
Autor/es principal/es: | Valdor, Rut Schreiber, Valerie Saenz, Luis Martínez, Teresa Munoz Suano, Alba Dominguez Villar, Margarita Ramírez, Pablo Parrilla, Pascual Aguado, Enrique García Cózar, Francisco Yélamos, José |
Facultad/Departamentos/Servicios: | Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Bioquímica y Biología Molecular "B" e Inmunología |
URI: | http://hdl.handle.net/10201/138879 |
DOI: | https://doi.org/10.1016/j.molimm.2007.10.044 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 9 |
Derechos: | info:eu-repo/semantics/embargoedAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
Descripción: | ©2007. This document is the published, version of a Published Work that appeared in final form in Molecular Immunology. To access the final edited and published work see https://doi.org/10.1016/j.molimm.2007.10.044 |
Aparece en las colecciones: | Artículos: Bioquímica y Biología Molecular "B" e Inmunología |
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Fichero | Descripción | Tamaño | Formato | |
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