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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Valdor, Rut | - |
dc.contributor.author | Schreiber, Valerie | - |
dc.contributor.author | Saenz, Luis | - |
dc.contributor.author | Martínez, Teresa | - |
dc.contributor.author | Munoz Suano, Alba | - |
dc.contributor.author | Dominguez Villar, Margarita | - |
dc.contributor.author | Ramírez, Pablo | - |
dc.contributor.author | Parrilla, Pascual | - |
dc.contributor.author | Aguado, Enrique | - |
dc.contributor.author | García Cózar, Francisco | - |
dc.contributor.author | Yélamos, José | - |
dc.contributor.other | Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Bioquímica y Biología Molecular "B" e Inmunología | - |
dc.date.accessioned | 2024-02-07T11:57:42Z | - |
dc.date.available | 2024-02-07T11:57:42Z | - |
dc.date.issued | 2007-10-31 | - |
dc.identifier.citation | Molecular Immunology 45 (2008) 1863–1871 | - |
dc.identifier.issn | Print: 0161-5890 | - |
dc.identifier.uri | http://hdl.handle.net/10201/138879 | - |
dc.description | ©2007. This document is the published, version of a Published Work that appeared in final form in Molecular Immunology. To access the final edited and published work see https://doi.org/10.1016/j.molimm.2007.10.044 | - |
dc.description.abstract | The nuclear factor of activated T cells (NFAT) family of transcription factors is pivotal for T lymphocyte functionality. All relevant NFAT activation events upon T cells stimulation such as nuclear translocation, DNA binding, and transcriptional activity have been shown to be dictated by its phosphorylation state. Here, we provide evidence for a novel post- translational modification that regulates NFAT. Indeed, NFATc1 and NFATc2 are poly(ADP-ribosyl)ated by poly-ADP-ribose polymerase-1 (PARP-1). Moreover, we have also found a physical interaction between PARP-1 and both NFATc1 and NFATc2. Interestingly, PARP is activated during T cell stimulation in the absence of DNA damage, leading to ADP-ribose polymers formation and transfer to nuclear acceptor proteins. Our data suggest that poly(ADP-ribosyl)ation modulates the activation of NFAT in T cells, as PARP inhibition causes an increase in NFAT-dependent transactivation and a delay in NFAT nuclear export. Poly(ADPribosyl)ation will expedited NFAT export from the nucleus directly or by priming/facilitating NFAT phosphorylation. Altogether, these data point to PARP-1 and poly(ADP-ribosyl)ation as a novel regulatory mechanism of NFAT at nuclear level, suggesting a potential use of PARP as a new therapeutic target in the modulation of NFAT. | - |
dc.format | application/pdf | es |
dc.format.extent | 9 | - |
dc.language | eng | es |
dc.publisher | Elsevier | - |
dc.relation | This work was supported by The Spanish Ministerio de Educacion y Ciencia (grants BIO-2005- ´ 01393, SAF2005-00458, Programa Ramon y Cajal to FJGC), ´ Instituto de Salud Carlos III (grant CP06/00021), Fundacion´ Seneca (grants 00603/PI/0403055/PI/05) and funds from The ´Centre National de la Recherche Scientifique, Association pour la Recherche contre le Cancer, Electricite de France, Comit ´ e du ´ Haut-Rhin de la Ligue Nationale Contre le Cancer and Commissariat a l’Energie Atomique. RV, MDV, and AMS are graduate ` fellows from Fundacion S ´ eneca, Instituto de Salud Carlos III ´ and Junta de Andalucia, respectively. | es |
dc.rights | info:eu-repo/semantics/embargoedAccess | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | - |
dc.subject | NFAT | - |
dc.subject | Nuclear retention | - |
dc.subject | Poly-ADP ribose polymerases | - |
dc.subject | Poly(ADP-ribosyl)ation | - |
dc.title | Regulation of NFAT by poly(ADP-ribose) polymerase activity in T cells | es |
dc.type | info:eu-repo/semantics/article | es |
dc.embargo.terms | Si | - |
dc.identifier.doi | https://doi.org/10.1016/j.molimm.2007.10.044 | - |
Aparece en las colecciones: | Artículos: Bioquímica y Biología Molecular "B" e Inmunología |
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mollecular immunol.pdf | 1,18 MB | Adobe PDF | Visualizar/Abrir Solicitar una copia |
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