Histology and histopathology Vol. 2, nº 4 (1987)

Ir a Estadísticas

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    Interstitial collagen in alcoholic human liver
    (Murcia : F. Hernández, 1987) Stenbäck, F.; Wasenius, Veli-Matti; Sotaniemi, Eero A.
    The occurrence and intensity of staining for specific antibodies against the aminoterminal propeptide of type 111 procollagen (PIIIP), which is indicative of the synthesis and the degradation of that collagen type, was studied in sections from normal and alcoholic livers and compared with serum PIIIP levels, serum antipyrine clearance, fibronectin distribution and morphology as revealed by conventional stains and electronmicroscopy. Positive staining for PIIIP and fibronectin was observed in the perisinusoidal space of the normal liver and in portal tracts. In alcohol-induced fatty liver positive staining increased around the central veins, in alcoholic hepatitis increased staining reaction was seen to a limited extent in areas of cell injury. Extensive reticulin and PIIIP-positive areas were found in the periportal interstitium of the cirrhotic livers and in large fibrotic areas extending into the surrounding parenchyma in cases of active disease. The results show a distinct relationship between collagen type 111 metabolism, morphologically detectable hepatic injury and liver cell function tests, with tissue deposition occurring later in the disease process than biochemically detectable serum collagen levels and signs of altered liver cell function.
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    Secondary amyloidosis and cystic fibrosis. A morphological and histochemical study of five cases
    (Murcia : F. Hernández, 1987) Bontempini, L.; Ghimenton, C.; Colombari, R.; Malena, M.; Luzzolino, P.; Canciani, M.; Doglioni, C.; Sbabo, L.
    The pathological findings of five cases of amyloidosis associated with Cystic Fibrosis are reported. Rectal biopsy led to the diagnosis of amyloidosis in four patients. In three cases the diagnosis was confirmed at autopsy , with involvement of spleen, liver, kidneys, adrenal glands, thyroid and other organs. It seems that Secondary Amyloidosis provokes a significant, although rare, complication of Cystic Fibrosis as greater numbers of these patients survive into adulthood.
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    Electron microscopic studies on the pars intermedia of the rat under stress
    (Murcia : F. Hernández, 1987) Blasco, J.; Martínez, C.; Gómez, E.; Sarrat, R.
    Using electron microscopy. we have studied the pars intermedia (PI) of the pituitary gland of Wistar rat under psychogenic stress, finding a considerable increase in dark cells. The cells of the PI present striking vacuoles in al1 their cytoplasms, increasing up to a phase of total cellular disintegration. We have also observed a cell type, not found in the animal control group, of regular size and electrodense matrix of medium contrast.
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    Morphometric study of hepatic ultrastructure in alcoholic hepatitis
    (Murcia : F. Hernández, 1987) Chen, T.S.; Murphy, D.P.; Marquet, G.; Chedid, A.; Mendenhall, C.L.; Rabin, L.; Veterans Administration Cooperative Study Group on Alcoholic Hepatitis
    We undertook a morphometric analysis of hepatocellular organelles in an attempt to correlate their changes with the clinical stages of patients.with alcoholic hepatitis. Although hepatic ultrastructural alterations did not correlate with disease severity, we found significant differences between patient and control groups in the measured parameters of non-organelle cytoplasm, mitochondria, SER, RER, glycogen, and lipid.
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    Ultrastructure of the tubular nephron of Testudo graeca (Chelonia). A comparison between hibernating and non-hibernating animals
    (Murcia : F. Hernández, 1987) Zuasti, A.; Ferrer, C.; Ballesta Germán, José; Pastor García, Luis Miguel
    The tubular nephron of hibernating and nonhibernating specimens of Testudo graeca (Chelonia) was studied by means of conventional light and electron microscopy and histochemistry. The tubular nephron was composed of proximal, intermediate, distal and collecting tubules in both hibernating and nonhibernating animals. The cells of the proximal tubule showed long microvilli, cytoplasmic vacuoles, a developed endoplasmic reticulum and abundant mitochondria. Fat droplets were also observed. The intermediate segment was lined by ciliated and nonciliated cells. The lining cells of the distal tubule presented few microvilli, abundant dense mitochondria and clear vesicles of mucous appearance in the terminal portion. Collecting ducts are composed of mucous and non-mucous cells. Mucous cells presented strong reaction to the histochemical techniques detecting sialoand sulpho-mucins. During hibernation, a progressive vacuolar degeneration of the endoplasmic reticulum was observed in al1 the segments of tubular nephron, which may be caused by a massive intake of extracellular water into the cell.