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Es el depósito que recoge las revistas tanto impresas como electrónicas, editadas por la Universidad de Murcia. En este depósito se pueden consultar los artículos de las revistas a texto completo, con el objeto de aumentar la visibilidad de dichos trabajos, así como de preservar sus contenidos.
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- PublicationOpen AccessEl Perfil de la biblioteca y sus profesionales en la literatura infantil y juvenil(Universidad de Murcia, Servicio de Publicaciones, 2025) García Rodríguez, Araceli; Ferreira Días da Silva, Isabelle; Sin departamento asociadoBased on the idea of the need to modify the image that society has of libraries and their professionals in children's and young adult literature, the aim of this article is to analyse the text and illustrations of 40 titles for children and young adults. A quantitative analysis of different variables such as age, literary genre, subjects, type of library and its role in the plot, vision of the building, sex, role or condition, physical characteristics and functions of the professionals is carried out. It is concluded that these are mainly novels and stories aimed at an audience between 4 and 9 years old, in which public libraries predominate, appearing as a simple scenario and in which mainly women work, performing the most traditional professional tasks, but with a clear predominance of reading encouragement and with a generally positive vision.
- PublicationOpen AccessInserciones en circuitos ideológicos, o la desobediencia silenciosa de Cildo Meireles, Grup de Treball y Equipo Santiago & Bruscky(Universidad de Murcia, Servicio de Publicaciones, 2025) Garnier Rojas, Colombe; DepartamentosEste artículo trata sobre tres intervenciones artísticas de los años setenta en las cuales se emplean distintos canales de comunicación, controlados por regímenes autoritarios, para lanzar mensajes subversivos que invitan al pensamiento crítico. Se realiza un análisis comparativo de estos tres casos de estudio, alejados geográficamente, pero que comparten el contexto de represión proveniente de una dictadura militar, tanto en Brasil como en España: Inserções em circuitos ideológicos de Cildo Meireles (1970), Anunciamos de Grup de Treball (1973) y Revista clasificada de Equipe Bruscky & Santiago (1978). Un estudio de las obras desde su materialidad nos permite identificar las estrategias utilizadas y sus espacios de actuación, examinando su tentativa de comunicar con un público nuevo, a partir de su introducción dentro de un circuito preexistente. A través de estas acciones, se explora cómo una intervención artística que opera al interior de elementos o estructuras de la vida cotidiana, como pueden ser productos de consumo o medios de comunicación de masas, permite crear narrativas de resistencia frente a una situación socio-política compleja.
- PublicationOpen AccessStructure and hormonal output of the adrenal gland after experimental estrogenization of male rats(Universidad de Murcia, Departamento Histología e Histopatología, 2025) Pavle Ćosić; Svetlana Trifunović; Branka Šošić-Jurjević; Marko Miler; Branko Filipović; Milica Manojlović-Stojanoski; Vladimir Ajdžanović; Histología e HistopatologíaOrchidectomy and estrogenization of the male represent a procedure that is applicable in sex reassignment or in prostate cancer therapy. This approach has an influence on the hypothalamic-pituitaryadrenal axis and thus affects cardiovascular function and metabolism. We utilized orchidectomized rats to evaluate the effects of estradiol on the structure and hormonal output of the adrenal gland. Adult Wistar rats were divided into sham-operated (SO; n=7), orchidectomized (Orx; n=7), and estradiol-treated orchidectomized (Orx+E; n=7) groups. Estradiol-dipropionate (0.625 mg/kg b.m.) was administered subcutaneously for three weeks, while the SO and Orx groups received vehicle alone. Set objectives were achieved using histochemistry/immunohistochemistry, stereology, and immunoassays. In Orx+E rats, the hormonal milieu was characterized by decreased testosterone and increased ACTH, compared with the Orx group. Also, orchidectomy and estradiol treatment provoked a significant increase in adrenal cortex volume and volume of ZF per se, with increased cell and nuclei volumes in all three adrenocortical zones (ZG, ZF, and ZR), in comparison with Orx rats. Concentrations of aldosterone in blood, as well as corticosterone in blood and adrenal tissue were increased, while circulating DHEA was decreased (with increased immuno-expression of adrenocortical CYP 17 enzyme), all in Orx+E compared with Orx animals. The wide zonal distribution of VEGF and the pronounced blood supply within the ZF of Orx+E animals acted to support the synthesis and secretion of corticosteroids. These results seem cautionary in the context of young male estrogenization, given the negative impact of high mineralocorticoids and glucocorticoids on cardiovascular function and metabolism.
- PublicationOpen AccessUse of digital image analysis to improve rigor and efficiency of physeal bone growth measurements(Universidad de Murcia, Departamento Histología e Histopatología, 2025) Jay Byrd; Bria Foley; Alexander Farell; Garret Williams; Max Twedt; James Sypherd; Ellen Leiferman; Cameron Jeffers; Matthew A. Halanski; Grant Ozaki; Histología e HistopatologíaIn larger, translational animal models, manual measurements of longitudinal bone growth using fluorochrome labels is tedious and may be prone to less rigor due to variations in reader experience, sampling differences, and photobleaching that limits the repeatability of measurements. This study assesses the reliability of three different digital methods to assist in measurement of distance between pulsed fluorochrome labels. Forty-five tibial physes from skeletally immature New Zealand White rabbits were pulsed with fluorochrome labels and measured using Fully Manual Technique (FMT), Manual Digital Measurement (MDM), Computer Assisted Image Processing (AIP), and Fully Automated Measurement (FAM). Pearson’s correlation coefficient and Bland-Altman analysis were used to analyze the different methods. Intraclass correlation coefficient (ICC) assessed inter- and intrareader reliability. Regardless of the method, all growth rate measurement techniques exhibited excellent agreement and reliability. The computer assisted methods allowed rapid data acquisition without compromising reliability, thereby improving efficiency in bone growth research. Clinical Significance: Distances between fluorochrome bone labels on large samples can be reliably measured using digital imaging and processing techniques.
- PublicationOpen AccessUV-Fixed-Thick-Blotch preparation improves sensitivity of Auramine staining(American Society for Microbiology, 2013) Muñoz Dávila, M.J.; Martínez-Lirola, M.J.; Cejudo-García, M.A.; Genética y MicrobiologíaWe describe here a very simple modification of the auramine staining procedure based on preparation of a UV-fixed thick blotch which allowed us to reach an overall sensitivity of 0.82 (592 acid-fast bacillus [AFB]-positive specimens/722 initial respiratory specimens with positive mycobacterial culture) and sensitivities of 0.93 (526 AFB-positive specimens/564 culture-positive specimens) for Mycobacterium tuberculosis complex and 0.42 (66 AFB-positive specimens/158 culture-positive specimens) for nontuberculous mycobacteria.
- PublicationOpen AccessValue of the combination of intraepithelial tumor-infiltrating lymphocyte density and the heterogeneity of density as a prognostic marker in stage III colorectal cancers(Universidad de Murcia, Histología e Histopatología, 2025) Lingyan Jin; Hye Yeong Jin; Seung Yeon Yoo; Nam-Yun Cho; Jeong Mo Bae; Jung Ho Kim; Hye Seung Lee; Gyeong Hoon Kang; Sin departamento asociadoTumor-infiltrating lymphocyte (TIL) density is both a prognostic and a predictive factor in colorectal cancer (CRC). Whether the heterogeneity of TIL density across the tumor plays an important role in the clinical outcome of CRC is not well known. Adjuvant chemotherapy-treated patients with stage III CRC were analyzed for survival according to TIL density and density heterogeneity, which were determined on CD8-immunostained slides using a machine learning method and by calculating the Simpson evenness index, respectively. High heterogeneity of the intraepithelial TIL density was found to be an independent prognostic factor, with a hazard ratio of 1.970 (1.207-3.215) in the multivariate analysis of recurrence-free survival. High heterogeneity was closely associated with a high T category, venous invasion, perineural invasion, and KRAS mutation. The combination of both intraepithelial TIL density and density heterogeneity was significantly associated with the prognosis of patients: low TIL density/high TIL heterogeneity showed hazard ratios of 3.284 (1.639- 6.578) and 4.176 (1.713-10.178) in the discovery and validation cohorts, respectively. Our findings suggest that the heterogeneity status of intraepithelial TIL density might help delineate patients with better vs. worse survival when combined with intraepithelial TIL density.