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Investigación contiene los documentos generados por los docentes e investigadores de la Universidad en su labor de investigación. Este depósito tiene como objetivos el almacenamiento, la gestión, la preservación y la difusión de estos documentos, y pretende contribuir al aumento de la visibilidad del trabajo desarrollado por los miembros de la comunidad universitaria.
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Browsing Investigación by browse.metadata.subjectods "Objetivo 3: Salud"
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- PublicationOpen AccessA simple MALDI–TOF-MS method for the identification of non-mycobacterial aerobic actinomycetes growing on blood agar subcultures from positive MGIT cultures(Elsevier, 2025) Muñoz-Dávila, María José; Cabezas Fernández, María Teresa; Esteban García, Ana Belén; Martínez Lorila, Miguel José; Genética y Microbiología
- PublicationOpen AccessCould estrogen and progesterone be used as biomarkers in swine saliva?(Colégio Brasileiro de Reprodução Animal - CBRA, 2024) Armando Quintero Moreno, María Serrano Albal, María D. Barceló Campoy, Raquel Romar, Joaquín Gadea; FisiologíaEstradiol (17-beta-estradiol, E2) and progesterone (P4) play a key role in the regulation of the estrous cycle, and their determination is performed in blood plasma (BP) or serum. Blood collection in pigs is stressful for the animals and requires immobilization for an optimal collection. Saliva is also useful for monitoring ovulation, assessing ovarian function, or testing for pregnancy. Furthermore, its collection is more convenient and less invasive for frequent sampling. Despite these advantages, studies on sex hormones in swine saliva are very scarce, which limits their practical application. In the present study, the levels of E2 and P4 in saliva and BP were obtained to determine the potential association between them, and to verify if saliva could be used to monitor the reproductive status in sows. Twenty-seven hormonally synchronized (PgF2α, eCG and hCG) sows were sampled 24 hours after the onset of estrus and artificially inseminated. For saliva sampling, sows chewed a zip tied sponge for 15 to 30 seconds; then the sponge was removed from the zip tie and placed in a tube designed for human saliva collection (Salivette®). In the laboratory, the saliva was centrifuged at 1000 rpm for 5 min and stored in 1.5 ml cryovials at -80ºC until analysis. Blood sample was collected from the external jugular vein under general anesthesia. Hormone concentrations in saliva and BP were determined using a solid-phase, enzyme-labeled competitive chemiluminescent enzyme immunoassay (Immulite 1000; Siemens Healthineers). E2 and P4 were detected in all plasma samples, but P4 was only detected in 12/27 (44.4%) saliva samples and 100% of plasma samples (minimum detection level >0.20 ng/ml). P4 levels were higher in plasma than in saliva (8.67±1.94 vs. 1.16±0.74 ng/ml, Wilcoxon non-parametric test, p=0.004), while E2 levels (54.09±6.52 vs. 78.73±8.24 pg/ml, p=0.003) and E2/P4 ratio (25.71±9.76 vs. 251.31±48.39, p=0.002) were higher in saliva than in plasma. The use of Bland-Altman plot to compare plasma and saliva values for E2, P4 and ratio E2/P4 confirmed the inconsistency of the results. This fact confirms that saliva is not a suitable fluid to determine P4 and E2 in pigs with this methodology, a fact that was later confirmed when saliva and BP were obtained from 2 additional pregnant sows (> 60 days of gestation), obtaining P4 values in saliva with a very low value (2.11 ng/ml) when in plasma was 23.38 ng/ml, while E2 was higher in saliva than in plasma (86.1 vs. 15.70 pg/ml). Further studies are needed to clarify the inconsistency of these results in order to use a less invasive technique such as saliva sampling to determine reproductive hormones and assess the reproductive status of gilts and sows.
- PublicationOpen AccessEpidemiological analysis of suicidal behaviour in Spain from 2017 to 2022 and comparative perspectives with Japan: a retrospective observational study(MDPI, 2025-02-20) Martínez-Rives, Noelia L. ; Babu, Hellen W. ; Kotera, Yasuhiro ; Martín Chaparro, María del Pilar; Colman, Rory D. ; Gilmour, Stuart ; Psiquiatría y Psicología Social; Facultad de Psicología y LogopediaBackground: Suicide is a significant public health issue globally. The patterns and disparities in suicide rates may have changed with the onset of the COVID-19 pandemic. Using epidemiological comparative studies, we can identify how suicide incidence is influenced by risk factors such as personal pressures and social support. This study analyses Spanish suicide data during the period from 2017 to 2022 and compares them with previously analysed data from Japan, with the aim of exploring the variability in suicide distribution in both countries. Methods: We used a retrospective observational design with national-level suicide data from Spain to estimate trends in suicide mortality over this period and compared these data with previously analysed data from Japan. Results: In Spain, no significant changes in suicide rates were found before and after the pandemic period, but notable monthly variations occurred at the pandemic’s onset in the youngest age group, highlighting the increase use of poisoning among women until 2020. In Japan, a notable variation was found following the pandemic. Specifically, older age groups and younger women were at higher suicide risk, while the suicide risk transitioned from younger to older ages between 2020 and 2021 among men. These changes are likely attributed to exacerbated socio-economic factors. A similar trend was observed in both countries based on sex with a different influence noted for women. Conclusions: This study offers detailed insight into the patterns and circumstances of suicide in these countries, offering a basis for future interventions and preventive measures. These comparisons emphasize the critical nature of suicide and underline the necessity for enhanced prevention efforts.
- PublicationOpen AccessPsychiatric comorbidity in intellectual developmental disorders: a systematic review(MA Healthcare , 2025-07-04) Astilleros Martínez, Borja; Martín Chaparro, María del Pilar; Kotera, Yasuhiro ; Psiquiatria y Psicología Social; Facultad de Psicología y LogopediaAims/Background Intellectual developmental disorders (IDD) are characterized by significant limita-tions in intellectual functioning and adaptive behavior, affecting conceptual, social, and practical skills. They impact 1% of the global population, with mild cases being more common. Major causes include prenatal, perinatal, and postnatal factors, although a clear cause is often not identified. This study aims to evaluate the comorbidity of psychological disorders in individuals diagnosed with IDD. Methods Following the “Preferred Reporting Items for Systematic reviews and Meta-Analyses” (PR-ISMA) statement, studies from 2014 to 2024 were considered using the databases Web of Science, PsycInfo, and PubMed. Articles focusing on psychopathology in individuals with IDD from birth were selected, excluding studies involving individuals under 16 years old and cases of severe and profound IDD. Results Of the 2895 articles retrieved, 11 were included. These studies showed heterogeneity in co-morbidities such as schizophrenia spectrum and other psychotic disorders, mood disorders, anxiety disorders, developmental disorders, personality disorders, substance use disorders, and adjustment and stress reaction disorders. Conclusion Individuals with IDD are more vulnerable to mental health conditions, underscoring the need for comprehensive assessments and multidisciplinary treatments to improve their quality of life and optimize public resources. Future research should develop validated diagnostic tools for IDD and conduct longitudinal studies on their impact on quality of life. It should also explore gender differences and address specific needs in disadvantaged contexts with tailored interventions.
- PublicationOpen AccessVarón marroquí con espondilodiscitis de larga evolución, orquitis y endocarditis(Asociación Colombiana de Medicina Interna, 2015-08-02) Marín, Antonio; Muñoz, María Ángeles; Rodriguez, Tomás; Muñoz-Dávila, María J.; Genética y MicrobiologíaOsteoarticular involvement is the most common complication of brucellosis. Spondylodiscitis is a serious complication as it is often associated with abscess formation. The case of a 43 years old man born in Morocco with symptoms, signs and imaging findings of longstanding spondylodiscitis, orchitis and endocarditis is presented. Through the implementation of complementary laboratory tests, diagnosis infection by Brucella spp. was made.This case aims to raise awareness in the medical community about the importance of considering Brucella spp. as a differential diagnosis in patients with suspected infectious spondylodiscitis, especially in those patients with epidemiological background, allowing make a successful and timely diagnosis. This case is interesting because never before had been described the simultaneous presence of these three manifestations of brucellosis in an immunocompetent patient. (Acta Med Colomb 2015; 40: 166-168).