Browsing by Subject "Spermatogonia stem cell"

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    The PI3K/AKT signaling pathway: How does it regulate development of Sertoli cells and spermatogenic cells?
    (Universidad de Murcia, Departamento de Biologia Celular e Histiologia, 2022) Chen, Kuang Qi; Wei, Bang Hong; Hao, Shuang Li; Yang, Wan Xi
    The PI3K/AKT signaling pathway is one of the most crucial regulatory mechanisms in animal cells, which can mainly regulate proliferation, survival and anti-apoptosis in cell lines. In the seminiferous epithelium, most studies were concentrated on the role of PI3K/AKT signaling in immature Sertoli cells (SCs) and spermatogonia stem cells (SSCs). PI3K/AKT signaling can facilitate the proliferation and antiapoptosis of immature Sertoli cells and spermatogenic cells. Besides, in mature Sertoli cells, this pathway can disintegrate the structure of the blood-testis barrier (BTB) via regulatory protein synthesis and the cytoskeleton of Sertoli cells. All of these effects can directly and indirectly maintain and promote spermatogenesis in male testis.