Publication:
The PI3K/AKT signaling pathway: How does it regulate development of Sertoli cells and spermatogenic cells?

Thumbnail Image
Files
Chen-37-621-636-2022.pdf(3.85 MB)
Date
2022
relationships.isAuthorOfPublication
relationships.isSecondaryAuthorOf
relationships.isDirectorOf
Authors
Chen, Kuang Qi ; Wei, Bang Hong ; Hao, Shuang Li ; Yang, Wan Xi
item.page.secondaryauthor
item.page.director
Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
publication.page.editor
publication.page.department
DOI
https://doi.org/10.14670/HH-18-457
item.page.type
info:eu-repo/semantics/article
Description
Abstract
The PI3K/AKT signaling pathway is one of the most crucial regulatory mechanisms in animal cells, which can mainly regulate proliferation, survival and anti-apoptosis in cell lines. In the seminiferous epithelium, most studies were concentrated on the role of PI3K/AKT signaling in immature Sertoli cells (SCs) and spermatogonia stem cells (SSCs). PI3K/AKT signaling can facilitate the proliferation and antiapoptosis of immature Sertoli cells and spermatogenic cells. Besides, in mature Sertoli cells, this pathway can disintegrate the structure of the blood-testis barrier (BTB) via regulatory protein synthesis and the cytoskeleton of Sertoli cells. All of these effects can directly and indirectly maintain and promote spermatogenesis in male testis.
publication.page.subject
PI3K/AKT signaling , Sertoli cell , Spermatogonia stem cell , Blood testis barrier , Spermatogenesis
Citation
URI
http://hdl.handle.net/10201/128692
item.page.embargo
Collections
Histology and histopathology Vol.37, nº7 (2022)
Ir a Estadísticas