Histology and histopathology Vol.20, nº 1 (2005)

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Effect of the arterial hypertension and captopril treatment on the angiotensin II content in the subfornical organ. A study in SHR rats
(Murcia : F. Hernández, 2005) Carmona-Calero, E.; Pérez-González, H.; Martínez de la Peña y Valenzuela, Isabel; Gonzalez-Marrero, I.; Perez-Garcia, C.G.; Marrero-Gordillo, N.; Ormazabal-Ramos, C.; Castañeyra Perdomo, A.; Ferres Torres, R.
We studied the effects of spontaneous high blood pressure and the captopril treatment on the subfornical organ (SFO) of rats. The brains of control Wistar-Kyoto rats (WKY), WKY rats treated with captopril (WKY-T), spontaneously hypertensive rats (SHR) and SHR rats treated with captopril (SHR-T) were processed immunohistochemically using antiangiotensin II as primary antibody. Immunorective material (IRM) for angiotensin II was observed in a group of neurons and some cells of the ependymal layer of the SFO in WKY rats. The angiotensin II immunoreactive (AGII-ir) in the SHR rats was decreased, showing positive reaction only in a few neurons, while captopril treatment induced an increase in immunoreactive material in hypertensive rats, but contrarily, the expression of AGII-ir in the WKY-T group was scarce. The variations of the angiotensin II observed in the SFO could be owing to an interaction between the hypertension and its captopril treatment.