Publication: Effect of the arterial hypertension
and captopril treatment on the angiotensin II
content in the subfornical organ. A study in SHR rats
Authors
Carmona-Calero, E. ; Pérez-González, H. ; Martínez de la Peña y Valenzuela, Isabel ; Gonzalez-Marrero, I. ; Perez-Garcia, C.G. ; Marrero-Gordillo, N. ; Ormazabal-Ramos, C. ; Castañeyra Perdomo, A. ; Ferres Torres, R.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
We studied the effects of spontaneous high
blood pressure and the captopril treatment on the
subfornical organ (SFO) of rats. The brains of control
Wistar-Kyoto rats (WKY), WKY rats treated with
captopril (WKY-T), spontaneously hypertensive rats
(SHR) and SHR rats treated with captopril (SHR-T)
were processed immunohistochemically using antiangiotensin
II as primary antibody. Immunorective
material (IRM) for angiotensin II was observed in a
group of neurons and some cells of the ependymal layer
of the SFO in WKY rats. The angiotensin II
immunoreactive (AGII-ir) in the SHR rats was
decreased, showing positive reaction only in a few
neurons, while captopril treatment induced an increase in
immunoreactive material in hypertensive rats, but
contrarily, the expression of AGII-ir in the WKY-T
group was scarce. The variations of the angiotensin II
observed in the SFO could be owing to an interaction
between the hypertension and its captopril treatment.
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